ArticleSurgical endoscopy2016
Prior treatment does not influence the performance or early outcome of per-oral endoscopic myotomy for achalasia.
Article in Surgical endoscopy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Efficacy and Safety of Peroral Endoscopic Myotomy in Achalasia Patients with Failed Previous Intervention: A Systematic Review and Meta-Analysis.Gut and liver · 2021Pooled it
- ACG Clinical Guidelines: Diagnosis and Management of Achalasia.The American journal of gastroenterology · 2020Guideline
- Updated Systematic Review of Achalasia, with a Focus on POEM Therapy.Digestive diseases and sciences · 2020Pooled it
- Aflatoxin influences achalasia symptomatology.Molecular medicine reports · 2020Trial
- Long-term efficacy of modified retrievable stents for treatment of achalasia cardia.Surgical endoscopy · 2016Trial
- Impact of prior endoscopic or surgical interventions on clinical outcomes after peroral endoscopic myotomy for achalasia.Surgical endoscopy · 2026Observational
- Peroral endoscopic myotomy: a Danish single center 10-year follow-up study.Surgical endoscopy · 2025Article
- Peroral endoscopic myotomy for the treatment of achalasia after failed pneumatic dilation.Surgical endoscopy · 2021Article
- Outcomes of peroral endoscopic myotomy in challenging achalasia patients: a long-term follow-up study.Surgical endoscopy · 2021Article
- Peroral endoscopic myotomy is highly effective for achalasia patients with recurrent symptoms after pneumatic dilatation.Surgical endoscopy · 2021Article
- Comparison of peroral endoscopic myotomy between de-novo achalasia and achalasia with prior treatment.Surgical endoscopy · 2021Article
- Peroral Endoscopic Myotomy, a Well-Established, Efficacious, and Safe Treatment Option for Achalasia: Is the History of Previous Treatment a Hurdle or Not?Clinical endoscopy · 2020Article
- 2007-2019: a "Third"-Space Odyssey in the Endoscopic Management of Gastrointestinal Tract Diseases.Current treatment options in gastroenterology · 2019Review
- Recent Advances in Third-Space Endoscopy.Gastroenterology & hepatology · 2018Article
- POEM in the Treatment of Esophageal Disorders.Current treatment options in gastroenterology · 2018Review
- Per-oral endoscopic myotomy for achalasia cardia: outcomes in over 400 consecutive patients.Endoscopy international open · 2017Article
- Impact of prior interventions on outcomes during per oral endoscopic myotomy.Surgical endoscopy · 2017Article
- POEM vs Laparoscopic Heller Myotomy and Fundoplication: Which Is Now the Gold Standard for Treatment of Achalasia?Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2017Article
- The current state of per oral endoscopic myotomy for achalasia.Journal of visualized surgery · 2017Review
- Peroral Endoscopic Myotomy for Treating Achalasia and Esophageal Motility Disorders.Journal of neurogastroenterology and motility · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPer-oral endoscopic myotomy (POEM) is an emerging treatment for achalasia. Pneumatic dilation, botulinum toxin injection, and previous myotomy increase the difficulty of subsequent Heller myotomy, but their impact on POEM remains unknown. The purpose of this study was to compare patients who had undergone prior treatment for their achalasia to those undergoing POEM as an initial therapy. METHODS AND PROCEDURES: All patients undergoing POEM were entered into a prospective database from August 2012 to October 2014. Data collected included demographics, dysphagia and symptom survey scores, operative time, clips required for mucosotomy closure, perioperative complications and length of hospital stay.
resultsForty-five patients underwent POEM during the study period. Fifteen (30%) had undergone previous treatment (seven Botox injection, five pneumatic dilation and three Heller myotomy). Primary POEM patients were younger than those who had had prior treatment (mean age 46 ± 17 vs. 64 ± 12 years, p < 0.001), but gender, body mass index and ASA class were not significantly different. There were no conversions to Heller myotomy or perioperative complications in either group. Operative time for primary POEM was 103 ± 27 versus 102 ± 29 min following prior treatment (p = 0.84). Mucosotomy closure required a median 7 (4-16) and 8 (5-16) clips, respectively (p = 0.08). Length of stay was 1 day in each group. Median dysphagia scores decreased from 4 (0-5) to 1 (0-4) following primary POEM and 4 (0-5) to 0 (0-4) in the prior treatment group (p = 0.45) during a median follow-up of 10 months (5-17 months). All patients in each group expressed satisfaction with their procedure and would undergo the procedure again given the benefit of hindsight.
conclusionPer-oral endoscopic myotomy is a safe and effective treatment for achalasia which improves dysphagia and disease-specific quality of life. Previous endoscopic or laparoscopic treatment of achalasia does not affect the performance or early outcome of POEM.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.