Evidence map›Paper›PMID 26123301›Full record

ReviewProgress in molecular biology and translational science2015

RGS Protein Regulation of Phototransduction.

Ching-Kang Jason Chen

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Progress in molecular biology and translational science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Ching-Kang Jason ChenDepartment of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA; Department of Neuroscience, Baylor College of Medicine, Houston, Texas, USA. Electronic address: Ching-Kang.Chen@bcm.edu.
Baylor College of Medicine · US

Funding

RECOVERY OF PHOTOTRANSDUCTIONR01EY013811 · NEI · VIRGINIA COMMONWEALTH UNIVERSITY · PI CHEN, CHING-KANG JASON · 2002 to 2017
$5.2M
The roles of Gbeta5 and R7 RGS protein in visionR01EY022228 · NEI · VIRGINIA COMMONWEALTH UNIVERSITY · PI CHEN, CHING-KANG JASON · 2012 to 2014
$1.1M
NEI NIH HHS R01 EY013811NEI NIH HHS R01 EY022228
6 · The paper itself

Abstract

First identified in yeast and worm and later in other species, the physiological importance of Regulators of G-protein Signaling (RGS) in mammals was first demonstrated at the turn of the century in mouse retinal photoreceptors, in which RGS9 is needed for timely recovery of rod phototransduction. The role of RGS in vision has also been established a synapse away in retinal depolarizing bipolar cells (DBCs), where RGS7 and RGS11 work redundantly and in a complex with Gβ5-S as GAPs for Goα in the metabotropic glutamate receptor 6 pathway situated at DBC dendritic tips. Much less is known on how RGS protein subserves vision in the rest of the visual system. The research into the roles of RGS proteins in vision holds great potential for many exciting new discoveries.

Indexed as

Light Signal TransductionAnimalsGTP-Binding ProteinsHumansMultiprotein ComplexesNeuronsPhotonsRGS ProteinsGTP-Binding ProteinsMultiprotein ComplexesRGS ProteinsDepolarizing bipolar cellHeterotrimeric G-proteinPhotoreceptorPhototransductionRate-limiting stepRegulators of G-protein SignalingRetinaVision

Identifiers

PMID26123301
PMCPMC4664578
OpenAlexW2401076913

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.