ArticleJournal of materials science. Materials in medicine2015
Chlorhexidine hexametaphosphate nanoparticles as a novel antimicrobial coating for dental implants.
Article in Journal of materials science. Materials in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Antimicrobial additives in resin-based endodontic sealers: a scoping review of antimicrobial efficacy, physicochemical properties, and cytotoxicity.Frontiers in dental medicine · 2026Pooled it
- Microbial Biofilm Decontamination on Dental Implant Surfaces: A Mini Review.Frontiers in cellular and infection microbiology · 2021Pooled it
- Nitric oxide‑releasing porous titanium foams fabricated by scalable sintering-dissolution process for antibiofilm activity and cytocompatibility.Scientific reports · 2026Article
- Dental devices and antimicrobial resistance: challenges, innovations, and regulatory compliances.Frontiers in medical technology · 2026Review
- Potential role of metal nanoparticles in treatment of peri-implant mucositis and peri-implantitis.Biomedical engineering online · 2024Review
- The Mitochondrial-Derived Peptide MOTS-c Alleviates Radiation Pneumonitis via an Nrf2-Dependent Mechanism.Antioxidants (Basel, Switzerland) · 2024Article
- Evaluation of polymethyl-methacrylate and acetal denture base resins processed by two different techniques before and after nano-chlorohexidine surface treatment.BMC oral health · 2023Article
- Biphasic Bioceramic Obtained from Byproducts of Sugar Beet Processing for Use in Bioactive Coatings and Bone Fillings.Journal of functional biomaterials · 2023Article
- A Novel Coating of Orthodontic Archwires with Chlorhexidine Hexametaphosphate Nanoparticles.International journal of biomaterials · 2023Article
- Classification and research progress of implant surface antimicrobial techniques.Journal of dental sciences · 2022Review
- A novel chlorhexidine-hexametaphosphate coating for titanium with antibiofilm efficacy and stem cell cytocompatibility.Journal of materials science. Materials in medicine · 2021Article
- Recent Advances in the Development of Antimicrobial and Antifouling Biocompatible Materials for Dental Applications.Materials (Basel, Switzerland) · 2021Review
- The efficacy of convenient cleaning methods applicable for customized abutments: an in vitro study.BMC oral health · 2021Article
- Local injection of a hexametaphosphate formulation reduces heterotopic ossificationMaterials today. Bio · 2020Article
- Studies on antimicrobial and wound healing applications of gauze coated with CHX-Ag hybrid NPs.IET nanobiotechnology · 2020Article
- Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment.Molecules (Basel, Switzerland) · 2020Review
- Application of Antimicrobial Nanoparticles in Dentistry.Molecules (Basel, Switzerland) · 2019Review
- Glass ionomer cements with milled, dry chlorhexidine hexametaphosphate filler particles to provide long-term antimicrobial properties with recharge capacity.Dental materials : official publication of the Academy of Dental Materials · 2018Article
- Nanosized Building Blocks for Customizing Novel Antibiofilm Approaches.Journal of dental research · 2017Review
- Microbial Profiles and Detection Techniques in Peri-Implant Diseases: a Systematic Review.Journal of oral & maxillofacial researchReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dental implants are an increasingly popular solution to missing teeth. Implants are prone to colonisation by pathogenic oral bacteria which can lead to inflammation, destruction of bone and ultimately implant failure. The aim of this study was to investigate the use of chlorhexidine (CHX) hexametaphosphate (HMP) nanoparticles (NPs) with a total CHX concentration equivalent to 5 mM as a coating for dental implants. The CHX HMP NPs had mean diameter 49 nm and composition was confirmed showing presence of both chlorine and phosphorus. The NPs formed micrometer-sized aggregated surface deposits on commercially pure grade II titanium substrates following immersion-coating for 30 s. When CHX HMP NP-coated titanium specimens were immersed in deionised water, sustained release of soluble CHX was observed, both in the absence and presence of a salivary pellicle, for the duration of the study (99 days) without reaching a plateau. Control specimens exposed to a solution of aqueous 25 µM CHX (equivalent to the residual aqueous CHX present with the NPs) did not exhibit CHX release. CHX HMP NP-coated surfaces exhibited antimicrobial efficacy against oral primary colonising bacterium Streptococcus gordonii within 8 h. The antimicrobial efficacy was greater in the presence of an acquired pellicle which is postulated to be due to retention of soluble CHX by the pellicle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.