Evidence map›Paper›PMID 26123212›Full record

ArticleSpinal cord2016

Discrepancies between clinical assessments of sensory function and electrical perceptual thresholds after incomplete chronic cervical spinal cord injury.

R A Macklin, V J Brooke, F J Calabro, P H Ellaway, M A Perez

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Spinal cord, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

R A MacklinDepartment of Physical Medicine and Rehabilitation, Center for the Neural Basis of Cognition, Systems Neuroscience Institute, University of Pittsburgh, Pittsburgh, PA, USA.
V J BrookeDepartment of Physical Medicine and Rehabilitation, Center for the Neural Basis of Cognition, Systems Neuroscience Institute, University of Pittsburgh, Pittsburgh, PA, USA.
F J CalabroDepartment of Physical Medicine and Rehabilitation, Center for the Neural Basis of Cognition, Systems Neuroscience Institute, University of Pittsburgh, Pittsburgh, PA, USA.
P H EllawayDepartment of Medicine, Division of Brain Sciences, Imperial College, London, UK.
M A PerezDepartment of Physical Medicine and Rehabilitation, Center for the Neural Basis of Cognition, Systems Neuroscience Institute, University of Pittsburgh, Pittsburgh, PA, USA.
Center for the Neural Basis of Cognition · USImperial College London · GBUniversity of Pittsburgh · US

Funding

Corticospinal Function after Spinal Cord InjuryR01NS090622 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PEREZ, MONICA A · 2014 to 2018
$1.6M
Neural Control of Bilateral Hand and Arm Movements After Spinal Cord InjuryR01NS076589 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PEREZ, MONICA A · 2011 to 2016
$1.6M
Enhancement of hand motor function after cervical spinal cord injuryI01RX000815 · VA · VETERANS HEALTH ADMINISTRATION · PI PEREZ, MONICA A · 2015 to 2018
–
NINDS NIH HHS R01 NS076589NINDS NIH HHS R01 NS090622RRD VA I01 RX000815
6 · The paper itself

Abstract

STUDY

designProspective experimental.

objectivesTo compare sensory function as revealed by light touch and pin prick tests of the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) and the electrical perceptual threshold (EPT) exams in individuals with chronic incomplete cervical spinal cord injury (SCI).

settingPittsburgh, United States.

methodsEPT was tested using cutaneous electrical stimulation (0.5 ms pulse width, 3 Hz) in 32 healthy controls and in 17 participants with SCI over key points on dermatomes C2 to T4 on each side of the body. Light touch and pin prick ISNCSCI scores were tested at the same key dermatomes in SCI participants.

resultsIn controls, EPT values were higher in older males (1.26±0.2 mA, mean±s.d.) compared with younger males (1.0±0.2 mA) and older females (0.9±0.2 mA), regardless of the dermatome and side tested. Fifteen out of the seventeen SCI participants showed that the level of sensory impairment detected by the EPT was below the level detected by the ISNCSCI (mean=4.5±2.4, range 1-9). The frequency distribution of EPTs was similar to older male controls in dermatomes above but not below the ISNCSCI sensory level. The difference between EPT and ISNCSCI sensory level was negatively correlated with the time post injury.

conclusionsThe results show that, in the chronic stage of cervical SCI, the EPT reveals spared sensory function at lower (~5) spinal segments compared with the ISNCSCI sensory exam. It is hence found that the EPT is a sensitive tool to assess recovery of sensory function after chronic SCI.

Indexed as

AdultAgedAged, 80 and overCase-Control StudiesCervical CordChronic DiseaseElectric StimulationFemaleHumansMaleMiddle AgedNeurologic ExaminationPsychophysicsSensory ThresholdsSeverity of Illness IndexSkin

Identifiers

PMID26123212
PMCPMC5558198
OpenAlexW840613294

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.