ArticleBMC infectious diseases2015
Scabies: an ancient global disease with a need for new therapies.
Article in BMC infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 85 citations in OpenAlex.
- Comparison of topical benzyl benzoate vs. oral ivermectin in treating scabies: A randomized study.Journal of the European Academy of Dermatology and Venereology : JEADV · 2023Trial
- Structure of a pH-sensitive pentameric ligand-gated ion channel from the Sarcoptes scabies mite.Nature communications · 2026Article
- Scabies as a Neglected Tropical Disease: A Comprehensive Review of Pathogenesis, Epidemiology, Clinical Manifestations, Diagnosis and Treatment.The Yale journal of biology and medicine · 2025Review
- Increasing trend of scabies in Belgium, 2000-2023.Archives of public health = Archives belges de sante publique · 2025Article
- Review
- Combination of Crusted Scabies with Bullous Scabies: A Rare Case.International medical case reports journal · 2023Article
- Antiparasitic Activity of Tea Tree Oil (TTO) and Its Components against Medically Important Ectoparasites: A Systematic Review.Pharmaceutics · 2022Review
- Crusted Scabies, a Neglected Tropical Disease: Case Series and Literature Review.Infectious disease reports · 2022Review
- Broadening the spectrum of ivermectin: Its effect onFrontiers in cellular and infection microbiology · 2022Article
- The Unmet Needs in Atopic Dermatitis Control in Latin America: A Multidisciplinary Expert Perspective.Dermatology and therapy · 2021Review
- Scabies in remote Aboriginal and Torres Strait Islander populations in Australia: A narrative review.PLoS neglected tropical diseases · 2021Review
- Risk factors associated with scabies infestation among primary schoolchildren in a low socio-economic area in southeast of Iran.BMC pediatrics · 2021Article
- [Parasitoses in childhood].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2021Review
- Classic and Non-classic (Surrepticius) Scabies: Diagnostic and Treatment Considerations.Cureus · 2020Article
- A forgotten parasitic infestation in an immunocompromised patient-a case report of crusted scabies.The Pan African medical journal · 2020Article
- Of microbes and mange: consistent changes in the skin microbiome of three canid species infected with Sarcoptes scabiei mites.Parasites & vectors · 2019Article
- Factors associated with scabies outbreaks in primary schools in Ethiopia: a case-control study.Research and reports in tropical medicine · 2019Article
- Infected with Scabies Again? Focus in Management in Long-Term Care Facilities.Diseases (Basel, Switzerland) · 2018Review
- Article
- Scabies in the age of increasing drug resistance.PLoS neglected tropical diseases · 2017Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundScabies is an ancient disease (documented as far back as 2500 years ago). It affects about 300 million people annually worldwide, and the prevalence is as high as about 60% in Indigenous and Torres Strait Islander children in Australia. This is more than six times the rate seen in the rest of the developed world. Scabies is frequently complicated by bacterial infection leading to the development of skin sores and other more serious consequences such as septicaemia and chronic heart and kidney diseases. This causes a substantial social and economic burden especially in resource poor communities around the world. DISCUSSION: Very few treatment options are currently available for the management of scabies infection. In this manuscript we briefly discuss the clinical consequences of scabies and the problems found (studies conducted in Australia) with the currently used topical and oral treatments. Current scabies treatment options are fairly ineffective in preventing treatment relapse, inflammatory skin reactions and associated bacterial skin infections. None have ovicidal, antibacterial, anti-inflammatory and/or anti-pruritic properties. Treatments which are currently available for scabies can be problematic with adverse effects and perhaps of greater concern the risk of treatment failure. The development of new chemical entities is doubtful in the near future. Though there may be potential for immunological control, the development of a vaccine or other immunotherapy modalities may be decades away. The emergence of resistance among scabies mites to classical scabicides and ineffectiveness of current treatments (in reducing inflammatory skin reactions and secondary bacterial infections associated with scabies), raise serious concerns regarding current therapy. Treatment adherence difficulties, and safety and efficacy uncertainties in the young and elderly, all signal the need to identify new treatments for scabies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.