Evidence map›Paper›PMID 26122803›Full record

Trial reportPediatrics2015

Umbilical Cord Milking Versus Delayed Cord Clamping in Preterm Infants.

Anup C Katheria, Giang Truong, Larry Cousins, Bryan Oshiro, Neil N Finer

4 registry-linked trialsOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 80 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 13 pooled it
20.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01866982 nacompletednot on this map

The PREMOD Trial: A Randomized Controlled Trial of Umbilical Cord Milking vs. Delayed Cord Clamping in Premature Infants

TypeinterventionalSponsorSharp HealthCareRan2013 to 2018Enrolled197ConditionsIntraventricular HemorrhageArmsUmbilical Cord Milking, Delayed Cord Clamping
NCT03200301 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Effect of Intact Umbilical Cord Milking Versus Immediate Cord Clamping on Neonatal Outcomes and First Year Neurodevelopmental Outcomes in Very Preterm Infants - A Randomised Controlled Trial

TypeinterventionalSponsorJubilee Mission Medical College and Research InstituteRan2018 to 2024Enrolled250ConditionsPreterm Infant, Umbilical Cord MilkingArmsIntact Umbilical Cord Milking
NCT03476980 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Two Year Developmental Follow-up for Premature Infants Receiving Milking or Delayed Cord Clamping: PREMOD2

TypeinterventionalSponsorSharp HealthCareRan2019 to 2024Enrolled1,200ConditionsNeurodevelopmental AbnormalityArmsRandomized to Umbilical Cord Milking at birth, Randomized to Delayed Cord Clamping at birth
NCT04413097 naactive not recruitingnot on this mapstarted 2021, after this paper: background citation

Delayed Cord Clamping With Oxygen In Extremely Low Gestation Infants

TypeinterventionalSponsorSharp HealthCareRan2021 to 2026Enrolled140ConditionsIVH- Intraventricular Hemorrhage, Extreme Prematurity, Hypoxia Neonatal, HyperoxiaArmsDelayed Cord Clamping with Low Oxygen concentration, Delayed Cord Clamping with High Oxygen concentration
3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 13 syntheses or guidelines pooled it, 224 citations in OpenAlex.

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  8. Antenatal and perinatal factors influencing neonatal blood pressure: a systematic review.Journal of perinatology : official journal of the California Perinatal Association · 2021
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Anup C KatheriaNeonatal Research Institute and anup.katheria@sharp.com.
Giang TruongDepartments of Pediatrics, and.
Larry CousinsSan Diego Perinatology, Sharp Mary Birch Hospital for Women and Newborns, San Diego, California;
Bryan OshiroObstetrics, Loma Linda Medical University, Loma Linda, California.
Neil N FinerNeonatal Research Institute and.
Loma Linda University Medical Center · USPediatrics and Genetics · USSharp Mary Birch Hospital for Women & Newborns · US

Funding

Evaluation of Umbilical Cord Milking on Systemic Blood Flow in Premature InfantsR03HD072934 · NICHD · SHARP MEMORIAL HOSPITAL · PI KATHERIA, ANUP C · 2013 to 2014
$126k
NICHD NIH HHS 5R03HD072934-02NICHD NIH HHS R03 HD072934
6 · The paper itself

Abstract

BACKGROUND AND

objectiveDelayed cord clamping (DCC) is recommended for premature infants to improve blood volume. Most preterm infants are born by cesarean delivery (CD), and placental transfusion may be less effective than in vaginal delivery (VD). We sought to determine whether infants <32 weeks born by CD who undergo umbilical cord milking (UCM) have higher measures of systemic blood flow than infants who undergo DCC.

methodsThis was a 2-center trial. Infants delivered by CD were randomly assigned to undergo UCM or DCC. Infants delivered by VD were also randomly assigned separately. UCM (4 strippings) or DCC (45-60 seconds) were performed. Continuous hemodynamic measurements and echocardiography were done at site 1.

resultsA total of 197 infants were enrolled (mean gestational age 28 ± 2 weeks). Of the 154 infants delivered by CD, 75 were assigned to UCM and 79 to DCC. Of the infants delivered by CD, neonates randomly assigned to UCM had higher superior vena cava flow and right ventricular output in the first 12 hours of life. Neonates undergoing UCM also had higher hemoglobin, delivery room temperature, blood pressure over the first 15 hours, and urine output in the first 24 hours of life. There were no differences for the 43 infants delivered by VD.

conclusionsThis is the first randomized controlled trial demonstrating higher systemic blood flow with UCM in preterm neonates compared with DCC. UCM may be a more efficient technique to improve blood volume in premature infants delivered by CD.

Indexed as

Cesarean SectionConstrictionDelivery, ObstetricFemaleGestational AgeHemodynamicsHumansInfant, NewbornInfant, PrematureMalePlacentaPregnancyUmbilical Cord

Identifiers

PMID26122803
PMCPMC4485011
OpenAlexW2098490373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.