ArticleBMC ophthalmology2015
Visual signs and symptoms in patients with the visual variant of Alzheimer disease.
Article in BMC ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Visual field defects in dementia: A scoping review.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Pooled it
- Retinal Microstructural and Microvascular Changes in Alzheimer Disease: A Review.International ophthalmology clinics · 2025Review
- Article
- Rationale and design of the BeyeOMARKER study: prospective evaluation of blood- and eye-based biomarkers for early detection of Alzheimer's disease pathology in the eye clinic.Alzheimer's research & therapy · 2024Observational
- Alzheimer's disease pathophysiology in the Retina.Progress in retinal and eye research · 2024Review
- Review
- Article
- Alzheimer's Disease Seen through the Eye: Ocular Alterations and Neurodegeneration.International journal of molecular sciences · 2022Review
- Association of cognitive function with Neurofilament light chain in the aqueous humor of human eye.Frontiers in aging neuroscience · 2022Article
- Executive dysfunction contributes to verbal encoding and retrieval deficits in posterior cortical atrophy.Cortex; a journal devoted to the study of the nervous system and behavior · 2018Article
- Differentiation of neuropsychological features between posterior cortical atrophy and early onset Alzheimer's disease.BMC neurology · 2018Article
- Visual Features in Alzheimer's Disease: From Basic Mechanisms to Clinical Overview.Neural plasticity · 2018Review
- Consensus classification of posterior cortical atrophy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2017Article
- Homonymous Hemianopsia Due to Posterior Cortical Atrophy.Neuro-ophthalmology (Aeolus Press) · 2017Article
- Lateralized occipital degeneration in posterior cortical atrophy predicts visual field deficits.NeuroImage. Clinical · 2017Article
- The Eye As a Biomarker for Alzheimer's Disease.Frontiers in neuroscience · 2016Review
- Visual and Ocular Manifestations of Alzheimer's Disease and Their Use as Biomarkers for Diagnosis and Progression.Frontiers in neurology · 2016Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProminent visual symptoms can present in the visual variant of Alzheimer's disease (VVAD). Ophthalmologists have a significant role to play in the early diagnosis of VVAD.
methodsWe retrospectively reviewed the files of ten consecutive patients diagnosed with VVAD. All patients had a full neuro-ophthalmologic examination, a formal neurological and neuro-psychological testing, and cerebral MRI to confirm diagnosis. In addition, functional neuroimaging was obtained in seven patients.
resultsThe common primary symptom at presentation with all patients was difficulty with near vision (reading difficulty n = 8, "visual blur" in near vision n = 2), and difficulty writing (n = 3). Following assessment, impaired reading and writing skills were evident in 9/10 and 8/10 patients respectively. Median distance visual acuity was 20/25 and at near the median visual acuity was J6. Partial homonymous visual field defect was detected in 80 % (8/10) of the patients. Color vision was impaired in all patients when tested with Ishihara pseudoisochromatic plates, but simple color naming was normal in 8/9 tested patients. Simultanagnosia was present in 8/10 patients. Vision dysfunction corresponded with cerebral MRI findings where parieto-occipital cortical atrophy was observed in all patients. PET scan (5 patients) or SPECT (2 patients) revealed parieto-occipital dysfunction (hypometabolism or hypoperfusion) in all 7 tested patients
conclusionsVisual difficulties are prominent in VVAD. Dyslexia, incomplete homonymous hemianopia, preserved color identification with abnormal color vision on Ishihara, and simultanagnosia were all symptoms observed frequently in this patient series. Ophthalmologists should be aware of the possibility of neurodegenerative disorders such as VVAD in patients with unexplained visual complaints, in particular reading difficulties.
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