ArticleCancer prevention research (Philadelphia, Pa.)2015
A Critical Examination of the "Bad Luck" Explanation of Cancer Risk.
Article in Cancer prevention research (Philadelphia, Pa.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- When Do Tumours Develop? Neoplastic Processes Across Different Timescales: Age, Season and Round the Circadian Clock.Evolutionary applications · 2024Review
- Stem cell mutations, associated cancer risk, and consequences for regenerative medicine.Cell stem cell · 2023Review
- The role of chance in cancer causation.La Medicina del lavoro · 2022Article
- Article
- Determining cancer risk: the evolutionary multistage model or total stem cell divisions?Proceedings. Biological sciences · 2020Article
- Review
- Comparative Oncology: New Insights into an Ancient Disease.iScience · 2020Review
- Tumorigenesis as the Paradigm of Quasi-neutral Molecular Evolution.Molecular biology and evolution · 2019Article
- Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets.Pharmaceuticals (Basel, Switzerland) · 2019Review
- Big Bang Tumor Growth and Clonal Evolution.Cold Spring Harbor perspectives in medicine · 2018Review
- A population genetics perspective on the determinants of intra-tumor heterogeneity.Biochimica et biophysica acta. Reviews on cancer · 2017Review
- Health Equity and the Fallacy of Treating Causes of Population Health as if They Sum to 100.American journal of public health · 2017Article
- Preventable Incidence and Mortality of Carcinoma Associated With Lifestyle Factors Among White Adults in the United States.JAMA oncology · 2016Article
- Cell Fusion in the War on Cancer: A Perspective on the Inception of Malignancy.International journal of molecular sciences · 2016Review
- Somatic mosaicism: on the road to cancer.Nature reviews. Cancer · 2016Review
- Stem cells, environment, and cancer risk.Stem cell investigation · 2015Article
- The Warburg Effect and Mass Spectrometry-based Proteomic Analysis.Cancer genomics & proteomicsReview
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Tomasetti and Vogelstein (1) argue that lifetime cancer risk for particular tissues is mostly determined by the total number of stem cell (SC) divisions within the tissue, whereby most cancers arise due to "bad luck"—mutations occurring during DNA replication. We argue that the poorly substantiated estimations of SC division parameters and assumptions that oversimplify somatic evolution prevent such a conclusion from being drawn.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.