Evidence map›Paper›PMID 26122376›Full record

ArticleAnnals of surgical oncology2015

A Comparison of Radiocolloid and Indocyanine Green Fluorescence Imaging, Sentinel Lymph Node Mapping in Patients with Cervical Cancer Undergoing Laparoscopic Surgery.

Sara Imboden, Andrea Papadia, Mélina Nauwerk, Brett McKinnon, Zahraa Kollmann, Stefan Mohr, Susanne Lanz, Michael D Mueller

Registry-linked trialOpen access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgical oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05167149 (A Randomized Controlled Comparison Study of Carbon Nanoparticles and Indocyanine Green for Sentinel Lymph Node Biopsy in Early Stage Cervical Cancer), which is not on this map. Cited by 45 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 5 pooled it
13.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05167149 naunknown statusnot on this mapstarted 2022, after this paper: background citation

A Randomized Controlled Comparison Study of Carbon Nanoparticles and Indocyanine Green for Sentinel Lymph Node Biopsy in Early Stage Cervical Cancer

TypeinterventionalSponsorCancer Institute and Hospital, Chinese Academy of Medical SciencesRan2022 to 2023Enrolled144ConditionsCervical Cancer Stage IB1ArmsCarbon nanoparticles, Indocyanine green
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 5 syntheses or guidelines pooled it, 83 citations in OpenAlex.

  1. Pooled it
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  17. Sentinel lymph node intraoperative analysis in endometrial cancer.Journal of cancer research and clinical oncology · 2020
    Article
  18. Review
  19. Article
  20. Current and novel mapping substances in gynecologic cancer care.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2020
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sara ImbodenDepartment of Obstetrics and Gynecology, University of Bern, Bern, Switzerland.
Andrea PapadiaDepartment of Obstetrics and Gynecology, University of Bern, Bern, Switzerland. andrea.papadia@insel.ch.
Mélina NauwerkDepartment of Obstetrics and Gynecology, University of Bern, Bern, Switzerland.
Brett McKinnonDepartment of Obstetrics and Gynecology, University of Bern, Bern, Switzerland.
Zahraa KollmannDepartment of Obstetrics and Gynecology, University of Bern, Bern, Switzerland.
Stefan MohrDepartment of Obstetrics and Gynecology, University of Bern, Bern, Switzerland.
Susanne LanzDepartment of Obstetrics and Gynecology, University of Bern, Bern, Switzerland.
Michael D MuellerDepartment of Obstetrics and Gynecology, University of Bern, Bern, Switzerland.
University of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purpose(99)TC combined with blue-dye mapping is considered the best sentinel lymph node (SLN) mapping technique in cervical cancer. Indocyanine green (ICG) with near infrared fluorescence imaging has been introduced as a new methodology for SLN mapping. The aim of this study was to compare these two techniques in the laparoscopic treatment of cervical cancer.

methodsMedical records of patients undergoing laparoscopic SLN mapping for cervical cancer with either (99)Tc and patent blue dye (Group 1) or ICG (Group 2) from April 2008 until August 2012 were reviewed. Sensitivity, specificity, and overall and bilateral detection rates were calculated and compared.

resultsFifty-eight patients were included in the study-36 patients in Group 1 and 22 patients in Group 2. Median tumor diameter was 25 and 29 mm, and mean SLN count was 2.1 and 3.7, for Groups 1 and 2, respectively. Mean non-SLN (NSLN) count was 39 for both groups. SLNs were ninefold more likely to be affected by metastatic disease compared with NSLNs (p < 0.005). Sensitivity and specificity were both 100 %. Overall detection rates were 83 and 95.5 % (p = nonsignificant), and bilateral detection rates were 61 and 95.5 % (p < 0.005), for Groups 1 and 2, respectively. In 75 % of cases, SLNs were located along the external or internal iliac nodal basins.

conclusionsICG SLN mapping in cervical cancer provides high overall and bilateral detection rates that compare favorably with the current standard of care.

Indexed as

LaparoscopyAdenocarcinomaAdultCarcinoma, Squamous CellColoring AgentsFemaleFollow-Up StudiesHumansIndocyanine GreenLymphatic MetastasisLymph NodesMiddle AgedNeoplasm StagingOptical ImagingPrognosisProspective StudiesColoring AgentsIndocyanine GreenRadiopharmaceuticalsTechnetium Tc 99m Sulfur Colloid

Identifiers

PMID26122376
PMCPMC4644188
OpenAlexW746189193

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.