Paracetamol-induced endocrine disruption in human fetal testes.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

10 citing papers in PubMed.

1. Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism.Proceedings of the National Academy of Sciences of the United States of America · 2018
   Trial
2. Paracetamol in pregnancy: Navigating clinical uncertainty and avoiding the communication pitfalls of the "measles, mumps, and rubella" - autism controversy: A narrative review.EXCLI journal · 2026
   Review
3. Acetaminophen Modulates the Expression of Steroidogenesis-Associated Genes and Estradiol Levels in Human Placental JEG-3 Cells.Toxicological sciences : an official journal of the Society of Toxicology · 2021
   Article
4. Association of Prenatal Acetaminophen Exposure Measured in Meconium With Risk of Attention-Deficit/Hyperactivity Disorder Mediated by Frontoparietal Network Brain Connectivity.JAMA pediatrics · 2020
   Observational
5. Associations between paracetamol (acetaminophen) intake between 18 and 32 weeks gestation and neurocognitive outcomes in the child: A longitudinal cohort study.Paediatric and perinatal epidemiology · 2020
   Article
6. Establishment and depletion of the ovarian reserve: physiology and impact of environmental chemicals.Cellular and molecular life sciences : CMLS · 2019
   Review
7. Long-term adverse effects of paracetamol - a review.British journal of clinical pharmacology · 2018
   Review
8. EDC IMPACT: Is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development?Endocrine connections · 2018
   Article
9. Ibuprofen results in alterations of human fetal testis development.Scientific reports · 2017
   Article
10. A Rat α-Fetoprotein Binding Activity Prediction Model to Facilitate Assessment of the Endocrine Disruption Potential of Environmental Chemicals.International journal of environmental research and public health · 2016
    Article

Corrections and comments

• Commented on by
  Endocrine disruptors: Reproductive consequences of analgesic use during pregnancy.2016
• Comment on
  Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model.2015

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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