ArticleBMC complementary and alternative medicine2015
Antibacterial and antibiotic resistance modifying activity of the extracts from Allanblackia gabonensis, Combretum molle and Gladiolus quartinianus against Gram-negative bacteria including multi-drug resistant phenotypes.
Article in BMC complementary and alternative medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 72 citations in OpenAlex.
- Phytochemical Composition and Antipseudomonal Activity ofScientifica · 2026Article
- Phytochemical Composition, Antibacterial Activity, Modes of Action, and Antibiotic Resistance-Modifying Effects ofScientifica · 2025Article
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- Elucidation of the mechanisms of fluconazole resistance and repurposing treatment options against urinary Candida spp. isolated from hospitalized patients in Alexandria, Egypt.BMC microbiology · 2024Article
- Phytochemical Composition, Antibacterial, and Antibiotic-Resistance Modulatory Activity of Extracts ofScientifica · 2024Article
- Antioxidant and Antibacterial Activities of the Leaf and Stem Extracts ofPlants (Basel, Switzerland) · 2023Article
- Ethnopharmacology, Antimicrobial Potency, and Phytochemistry of AfricanAntibiotics (Basel, Switzerland) · 2023Review
- Guttiferone BL from the Fruits ofBioMed research international · 2023Article
- Phytochemical screening, antimycobacterial activity and acute toxicity of crude extracts of selected medicinal plant species used locally in the treatment of tuberculosis in Uganda.Tropical medicine and health · 2022Article
- Resensitization of Fluconazole-Resistant UrinaryPolish journal of microbiology · 2020Article
- Antibacterial and antibiotic-modifying activities of fractions and compounds from Albizia adianthifolia against MDR Gram-negative enteric bacteria.BMC complementary and alternative medicine · 2019Article
- Antibacterial and Antibiotic Modifying Potential of Crude Extracts, Fractions, and Compounds fromEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Antibacterial and Antibiotic-Potentiating Activities of Thirteen Cameroonian Edible Plants against Gram-Negative Resistant Phenotypes.TheScientificWorldJournal · 2018Article
- Antibacterial activities of the methanol extracts ofSaudi journal of biological sciences · 2017Article
- Antibacterial and antibiotic resistance modulatory activities of leaves and bark extracts of Recinodindron heudelotii (Euphorbiaceae) against multidrug-resistant Gram-negative bacteria.BMC complementary and alternative medicine · 2017Article
- Antibacterial activities of the methanol extract, fractions and compounds from Elaeophorbia drupifera (Thonn.) Stapf. (Euphorbiaceae).BMC complementary and alternative medicine · 2017Article
- Antibacterial and antibiotic-resistance modifying activity of the extracts and compounds from Nauclea pobeguinii against Gram-negative multi-drug resistant phenotypes.BMC complementary and alternative medicine · 2016Article
- New Perspectives on the Use of Phytochemicals as an Emergent Strategy to Control Bacterial Infections Including Biofilms.Molecules (Basel, Switzerland) · 2016Review
- In vitro Antibacterial Activity of Combretum edwardsii, Combretum krausii, and Maytenus nemorosa and Their Synergistic Effects in Combination with Antibiotics.Frontiers in pharmacology · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBacterial resistance to antibiotics is becoming a serious problem worldwide. The discovery of new and effective antimicrobials and/or resistance modulators is necessary to tackle the spread of resistance or to reverse the multi-drug resistance. We investigated the antibacterial and antibiotic-resistance modifying activities of the methanol extracts from Allanblackia gabonensis, Gladiolus quartinianus and Combretum molle against 29 Gram-negative bacteria including multi-drug resistant (MDR) phenotypes.
methodsThe broth microdilution method was used to determine the minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations (MBC) of the samples meanwhile the standard phytochemical methods were used for the preliminary phytochemical screening of the plant extracts.
resultsPhytochemical analysis showed the presence of alkaloids, flavonoids, phenols and tannins in all studied extracts. Other chemical classes of secondary metabolites were selectively presents. Extracts from A. gabonensis and C. molle displayed a broad spectrum of activity with MICs varying from 16 to 1024 μg/mL against about 72.41% of the tested bacteria. The extract from the fruits of A. gabonensis had the best activity, with MIC values below 100 μg/mL on 37.9% of tested bacteria. Percentages of antibiotic-modulating effects ranging from 67 to 100% were observed against tested MDR bacteria when combining the leaves extract from C. molle (at MIC/2 and MIC/4) with chloramphenicol, kanamycin, streptomycin and tetracycline.
conclusionThe overall results of the present study provide information for the possible use of the studied plant, especially Allanblackia gabonensis and Combretum molle in the control of Gram-negative bacterial infections including MDR species as antibacterials as well as resistance modulators.
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