ArticleCell proliferation2015
Enhanced osteoconductivity of polyethersulphone nanofibres loaded with bioactive glass nanoparticles in in vitro and in vivo models.
Article in Cell proliferation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Novel Organic-Inorganic Nanocomposite Hybrids Based on Bioactive Glass Nanoparticles and Their Enhanced Osteoinductive Properties.Biomolecules · 2024Article
- Polyethersulfone Polymer for Biomedical Applications and Biotechnology.International journal of molecular sciences · 2024Review
- Open fractures: Current treatment perspective.OTA international : the open access journal of orthopaedic trauma · 2023Article
- Cell Scaffolds for Bone Tissue Engineering.Bioengineering (Basel, Switzerland) · 2020Article
- Electrospun PCL Fiber Mats Incorporating Multi-Targeted B and Co Co-Doped Bioactive Glass Nanoparticles for Angiogenesis.Materials (Basel, Switzerland) · 2020Article
- Enhancement of osteogenic differentiation of adipose-derived stem cells by PRP modified nanofibrous scaffold.Cytotechnology · 2018Article
- Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells in Electrospun Silica Nonwoven Fabrics.ACS omega · 2018Article
- Treatment of critical-sized bone defects: clinical and tissue engineering perspectives.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2018Review
- Effect of matrix stiffness on osteoblast functionalization.Cell proliferation · 2017Article
Corrections and comments
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesThere is growing need for new scaffold constructions for synthetic bone graft substitutes to repair large bone lesions. A very promising and important class of new implants for tissue engineering is based on three-dimensional scaffolds and bioceramics. MATERIALS AND
methodsIn this study, after investigation of mechanical properties of polyethersulphone (PES) nanofibres, fabricated by electrospinning methodology and coated with bioactive glass (BG), cells of the MG-63 line were cultured on surfaces of these scaffolds. Their capacity to support MG-63 proliferation was also investigated in vitro by MTT assay. Osteoconductivity on these scaffolds was investigated by the common osteogenic markers alkaline phosphatase (ALP) activity, calcium mineral deposition and bone-related gene activation. Next, a bone reconstruction of rat critical-size defects model was evaluated using radiographic imaging analysis (digital mammography), computed tomography and histological examination.
resultsIn vitro results indicated that biocompatibility and osteogenic markers of MG-63 cells were significantly enhanced after coating PES with BG. Based on in vivo results, new bone formation in the defect site was enhanced in implanted rats in comparison with a control group. The highest reconstruction was observed in animals implanted with BG-coated nanofibres.
conclusionsOsteoconductivity of PES nanofibres was markedly enhanced after coating them with BG, and introduction of this construct as new bone-graft substitute for bone loss and defects is indicated.
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