Evidence map›Paper›PMID 26121666›Full record

ArticlePloS one2015

Slow Cone Reflectance Changes during Bleaching Determined by Adaptive Optics Scanning Laser Ophthalmoscope in Living Human Eyes.

Masakazu Hirota, Suguru Miyagawa, Hiroyuki Kanda, Takao Endo, Tibor Karl Lohmann, Tomomitsu Miyoshi, Takeshi Morimoto, Takashi Fujikado

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Photoreceptor-Based Biomarkers in AOSLO Retinal Imaging.Investigative ophthalmology & visual science · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Masakazu HirotaDepartment of Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Suguru MiyagawaDepartment of Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; Fundamental Technology Sec, R&D Department, Topcon Corporation, Itabashi, Tokyo, Japan.
Hiroyuki KandaDepartment of Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Takao EndoDepartment of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Tibor Karl LohmannDepartment of Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; Department of Ophthalmology, University Hospital Aachen RWTH Aachen University, Aachen, Nordrhein-Westfalen, Germany.
Tomomitsu MiyoshiDepartment of Integrative Physiology, Graduate School of Medicine& Frontier Biosciences Osaka University, Suita, Osaka, Japan.
Takeshi MorimotoDepartment of Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Takashi FujikadoDepartment of Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate the changes in the reflectance of human cone photoreceptors by an adaptive optics scanning laser ophthalmoscope (AO-SLO) during photobleaching. A custom-built AO-SLO with an observation light of 840-nm was used to measure the cone densities and the reflectance changes during bleaching by 630 nm red light emitting diodes. Measurements were made at 1° and 3° temporal to the fovea within an area of 1° × 1° in 8 eyes of 8 normal subjects. After dark-adaptation, images of the cone mosaics were recorded continuously for 5-min before, 5-min during, and after 5-min of light stimulation with a sampling rate of 5-Hz. The first positive peak (P1) was observed at 72.2 ± 15.0-s and a second positive peak (P2) at 257.5 ± 34.5-s at 1°. The increase of the reflectance of P1 was significantly larger at 1° (34.4 ± 13.9%) than at 3° (26.0 ± 10.5%; P = 0.03, Wilcoxon's signed rank test). The average cone density at 1° (51123.13 ± 1401.23 cells/mm2) was significantly larger than that at 3° (30876.13 ± 1459.28 cells/mm2; P <0.001, Wilcoxon's signed rank test). The changes in the reflectance of the cones during bleaching by red light had two peaks. The two peaks may be caused by regeneration of cone photopigment during bleaching.

Indexed as

LasersOphthalmoscopesPhotobleachingAdaptation, OcularAdultFovea CentralisHumansOptics and PhotonicsPhotic StimulationRetinal Cone Photoreceptor CellsTime FactorsYoung Adult

Identifiers

PMID26121666
PMCPMC4488269

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.