Evidence map›Paper›PMID 26121662›Full record

ArticleAdvanced healthcare materials2015

Fabrication of 3D Scaffolds with Precisely Controlled Substrate Modulus and Pore Size by Templated-Fused Deposition Modeling to Direct Osteogenic Differentiation.

Ruijing Guo, Sichang Lu, Jonathan M Page, Alyssa R Merkel, Sandip Basu, Julie A Sterling, Scott A Guelcher

Abstract read
In one paragraph

Article in Advanced healthcare materials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Recent Advances in 3D Printing of Aliphatic Polyesters.Bioengineering (Basel, Switzerland) · 2017
    Review
  8. [The progress of research on three-dimensional printed jaw scaffolds].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2017
    Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ruijing GuoDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, 37212, USA.
Sichang LuDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, 37212, USA.
Jonathan M PageDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, 37212, USA.
Alyssa R MerkelDepartment of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, 37212, USA.
Sandip BasuAgilent Technologies, Chandler, AZ, USA.
Julie A SterlingDepartment of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, 37212, USA.
Scott A GuelcherDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, 37212, USA.

Funding

The Role of Mechanotransduction in Progression of Tumor-induced Bone DiseaseR01CA163499 · NCI · VANDERBILT UNIVERSITY · PI GUELCHER, SCOTT A, RHOADES (STERLING), JULIE A · 2012 to 2016
$1.5M
Targeting the Bone Microenvironment to Reduce Tumor-induced Bone DiseaseI01BX001957 · VA · VETERANS HEALTH ADMINISTRATION · PI RHOADES (STERLING), JULIE A · 2013 to 2025
–
BLRD VA I01 BX001957NCI NIH HHS CA163499NCI NIH HHS R01 CA163499
6 · The paper itself

Abstract

Scaffolds with tunable mechanical and topological properties fabricated by templated-fused deposition modeling promote increased osteogenic differentiation of bone marrow stem cells with increasing substrate modulus and decreasing pore size. These findings guide the rational design of cell-responsive scaffolds that recapitulate the bone microenvironment for repair of bone damaged by trauma or disease.

Indexed as

Cell DifferentiationOsteogenesisAnimalsCell MovementCell ProliferationCells, CulturedMesenchymal Stem CellsRatsRats, Sprague-DawleyTissue Scaffoldsfused deposition modelingmodulusosteogenic differentiationpore sizescaffolds

Identifiers

PMID26121662
PMCPMC4558627

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.