ArticlePloS one2015
Inter-Individual Differences in the Oral Bacteriome Are Greater than Intra-Day Fluctuations in Individuals.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 62 citations in OpenAlex.
- Ethnicity-specific microbiome in early childhood caries: a functional perspective of oral biofilm.mSystems · 2026Article
- Detection of Oral Bacterial DNA in Abdominal Aortic Aneurysm and Its Microbial Associations.International journal of molecular sciences · 2026Article
- The uropygial gland of the European hoopoe as a symbiotic organ.Animal microbiome · 2026Article
- Estimated predator composition using environmental DNA analyses and color patterns of male guppies in introduced rivers.Scientific reports · 2026Article
- DNA metabarcoding analysis revealed a silent prevalence of environmental pathogenicOne health (Amsterdam, Netherlands) · 2025Article
- Association of Adult Atopic Dermatitis with Impaired Oral Health and Oral Dysbiosis: A Case-Control Study.International dental journal · 2025Article
- Effect of implant abutment surface treatments on bacterial biofilm composition and structure.Journal of oral microbiology · 2025Article
- A systematic survey of environmental DNA in Palau's lakes and waterfalls reveals an increase inOne health (Amsterdam, Netherlands) · 2024Article
- The effect of dental material type and masticatory forces on periodontitis-derived subgingival microbiomes.Biofilm · 2024Article
- The abundance of the potential pathogen Staphylococcus hominis in the air microbiome in a dental clinic and its susceptibility to far-UVC light.MicrobiologyOpen · 2023Article
- Oral ecological environment modifications by hard-cheese: from pH to microbiome: a prospective cohort study based on 16S rRNA metabarcoding approach.Journal of translational medicine · 2022Article
- Analysis of human clinical and environmental Leptospira to elucidate the eco-epidemiology of leptospirosis in Yaeyama, subtropical Japan.PLoS neglected tropical diseases · 2022Article
- From Mouth to Brain: Distinct Supragingival Plaque Microbiota Composition in Cerebral Palsy Children With Caries.Frontiers in cellular and infection microbiology · 2022Article
- Optimizing the quality of clinical studies on oral microbiome: A practical guide for planning, performing, and reporting.Periodontology 2000 · 2021Review
- Functional Profiling Reveals Altered Metabolic Activity in Divers' Oral Microbiota During Commercial Heliox Saturation Diving.Frontiers in physiology · 2021Article
- Composition of nasal bacterial community and its seasonal variation in health care workers stationed in a clinical research laboratory.PloS one · 2021Article
- Oral microbiome and risk of malignant esophageal lesions in a high-risk area of China: A nested case-control study.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2020Article
- Understanding leptospirosis eco-epidemiology by environmental DNA metabarcoding of irrigation water from two agro-ecological regions of Sri Lanka.PLoS neglected tropical diseases · 2020Article
- Microbial biogeography and ecology of the mouth and implications for periodontal diseases.Periodontology 2000 · 2020Review
- Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project.Frontiers in cellular and infection microbiology · 2020Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Given the advent of massively parallel DNA sequencing, human microbiome is analyzed comprehensively by metagenomic approaches. However, the inter- and intra-individual variability and stability of the human microbiome remain poorly characterized, particularly at the intra-day level. This issue is of crucial importance for studies examining the effects of microbiome on human health. Here, we focused on bacteriome of oral plaques, for which repeated, time-controlled sampling is feasible. Eighty-one supragingival plaque subjects were collected from healthy individuals, examining multiple sites within the mouth at three time points (forenoon, evening, and night) over the course of 3 days. Bacterial composition was estimated by 16S rRNA sequencing and species-level profiling, resulting in identification of a total of 162 known bacterial species. We found that species compositions and their relative abundances were similar within individuals, and not between sampling time or tooth type. This suggests that species-level oral bacterial composition differs significantly between individuals, although the number of subjects is limited and the intra-individual variation also occurs. The majority of detected bacterial species (98.2%; 159/162), however, did not fluctuate over the course of the day, implying a largely stable oral microbiome on an intra-day time scale. In fact, the stability of this data set enabled us to estimate potential interactions between rare bacteria, with 40 co-occurrences supported by the existing literature. In summary, the present study provides a valuable basis for studies of the human microbiome, with significant implications in terms of biological and clinical outcomes.
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