Evidence map›Paper›PMID 26121484›Full record

ArticlePloS one2015

Assessment of Hemostasis after Plasma Exchange Using Rotational Thrombelastometry (ROTEM).

Gerold Thölking, Rolf Mesters, Ralf Dittrich, Hermann Pavenstädt, Philipp Kümpers, Stefan Reuter

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.

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  12. Albumin in adult cardiac surgery: a narrative review.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Gerold ThölkingDepartment of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Münster, Albert-Schweitzer-Campus 1, Münster, 48149, Germany.
Rolf MestersDepartment of Medicine A, Division of Hematology and Oncology, University Hospital of Münster, Albert-Schweitzer-Campus 1, Münster, 48149, Germany.
Ralf DittrichDepartment of Neurology, University Hospital of Münster, Albert-Schweitzer-Campus 1, Münster, 48149, Germany.
Hermann PavenstädtDepartment of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Münster, Albert-Schweitzer-Campus 1, Münster, 48149, Germany.
Philipp KümpersDepartment of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Münster, Albert-Schweitzer-Campus 1, Münster, 48149, Germany.
Stefan ReuterDepartment of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Münster, Albert-Schweitzer-Campus 1, Münster, 48149, Germany.
University Hospital Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTherapeutic plasma exchange (TPE)-based protocols immediately before cadaveric donor kidney transplantation have been extensively used in highly sensitized recipients. Plasma is generally preferred over human albumin as replacement fluid to avoid depletion of coagulation factors and perioperative bleeding. The aim of this study was to estimate bleeding risk after TPE replaced with albumin using rotational thromboelastography (ROTEM). METHODOLOGY: Ten patients without overt coagulation abnormalities underwent TPE. Standard laboratory coagulation tests (thromboplastin time, activated partial thromboplastin time (aPTT), international normalized ratio (INR), thrombin clotting time, fibrinogen levels and antithrombin activity) were compared with thrombelastometry analysis (EXTEM and INTEM tests) before and after TPE. PRINCIPAL

findingsTPE significantly reduced fibrinogen levels (482 ± 182 vs. 223 ± 122 mg/dL), antithrombin activity (103 ± 11 vs. 54 ± 11 %), and prolonged aPTT (28 ± 3 vs. 45 ± 8 s), thromboplastin time (108 ± 11 vs. 68 ± 11 %), INR (0.95 ± 0.06 vs. 1.25 ± 0.16), and thrombin clotting time (18 ± 2 vs. 20 ± 3 s). INTEM and EXTEM analyses revealed significantly prolonged clot-formation time and reduced maximum clot firmness. CONCLUSIONS/SIGNIFICANCE: TPE replaced with albumin induces significant changes in global hemostasis parameters thus potentially increasing bleeding risk. Therefore, pretransplant TPE should be considered carefully in indicated patients before kidney transplantation. The role of the ROTEM point-of-care test to estimate the risk of bleeding in renal transplantation needs to be evaluated in further studies.

Indexed as

HemostasisAdultAntithrombinsBlood CoagulationBlood Coagulation TestsCohort StudiesFemaleFibrinogenHemorrhageHumansInternational Normalized RatioMaleMiddle AgedPartial Thromboplastin TimePlasma ExchangePoint-of-Care SystemsAntithrombinsFibrinogenThrombin

Identifiers

PMID26121484
PMCPMC4488284
OpenAlexW1567255113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.