ArticlePloS one2015
Overexpression of Rat Neurons Nitric Oxide Synthase in Rice Enhances Drought and Salt Tolerance.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 107 citations in OpenAlex.
- Comparative physiological, hormonal, and transcriptional analyses reveal the difference between diploid and autotetraploid rice under cadmium stress.Plant cell reports · 2026Article
- Nitric oxide promotes cotton fiber initiation.Plant communications · 2026Article
- Genome-Wide Identification, Expression, and Functional Analysis of UDP-Glucose Dehydrogenase Family Genes inGenes · 2026Article
- Nitrate reductase-mediated production of nitric oxide enhances cold tolerance in rice seedlings.Scientific reports · 2026Article
- Amino Acid Regulation in Rice: Integrated Mechanisms and Agricultural Applications.Rice (New York, N.Y.) · 2025Review
- Exogenous Sodium Nitroprusside Affects the Redox System of Wheat Roots Differentially Regulating the Activity of Antioxidant Enzymes under Short-Time Osmotic Stress.Plants (Basel, Switzerland) · 2024Article
- Nitric Oxide (NO) Improves Wheat Growth under Dehydration Conditions by Regulating Phytohormone Levels and Induction of the Expression of thePlants (Basel, Switzerland) · 2023Article
- HbBIN2 Functions in Plant Cold Stress Resistance through Modulation of HbICE1 Transcriptional Activity and ROS Homeostasis inInternational journal of molecular sciences · 2023Article
- Article
- Multiple Ways of Nitric Oxide Production in Plants and Its Functional Activity under Abiotic Stress Conditions.International journal of molecular sciences · 2023Review
- Nitric Oxide in Plant Functioning: Metabolism, Signaling, and Responses to Infestation with Ecdysozoa Parasites.Biology · 2023Review
- Humic Acid Modulates Ionic Homeostasis, Osmolytes Content, and Antioxidant Defense to Improve Salt Tolerance in Rice.Plants (Basel, Switzerland) · 2023Article
- Functions of nitric oxide-mediated post-translational modifications under abiotic stress.Frontiers in plant science · 2023Review
- A Novel R2R3-MYB Transcription Factor FtMYB22 Negatively Regulates Salt and Drought Stress through ABA-Dependent Pathway.International journal of molecular sciences · 2022Article
- The Role of Nitric Oxide in Plant Responses to Salt Stress.International journal of molecular sciences · 2022Review
- ELO2 Participates in the Regulation of Osmotic Stress Response by Modulating Nitric Oxide Accumulation in Arabidopsis.Frontiers in plant science · 2022Article
- Overexpression of Orange Gene (Genes · 2021Article
- HbSnRK2.6 Functions in ABA-Regulated Cold Stress Response by Promoting HbICE2 Transcriptional Activity inInternational journal of molecular sciences · 2021Article
- Nitric oxide, crosstalk with stress regulators and plant abiotic stress tolerance.Plant cell reports · 2021Review
- Elevated Nitrogen Priming Induced Oxinitro-Responses and Water Deficit Tolerance in Rice.Plants (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) has been shown to play an important role in the plant response to biotic and abiotic stresses in Arabidopsis mutants with lower or higher levels of endogenous NO. The exogenous application of NO donors or scavengers has also suggested an important role for NO in plant defense against environmental stress. In this study, rice plants under drought and high salinity conditions showed increased nitric oxide synthase (NOS) activity and NO levels. Overexpression of rat neuronal NO synthase (nNOS) in rice increased both NOS activity and NO accumulation, resulting in improved tolerance of the transgenic plants to both drought and salt stresses. nNOS-overexpressing plants exhibited stronger water-holding capability, higher proline accumulation, less lipid peroxidation and reduced electrolyte leakage under drought and salt conditions than wild rice. Moreover, nNOS-overexpressing plants accumulated less H2O2, due to the observed up-regulation of OsCATA, OsCATB and OsPOX1. In agreement, the activities of CAT and POX were higher in transgenic rice than wild type. Additionally, the expression of six tested stress-responsive genes including OsDREB2A, OsDREB2B, OsSNAC1, OsSNAC2, OsLEA3 and OsRD29A, in nNOS-overexpressing plants was higher than that in the wild type under drought and high salinity conditions. Taken together, our results suggest that nNOS overexpression suppresses the stress-enhanced electrolyte leakage, lipid peroxidation and H2O2 accumulation, and promotes proline accumulation and the expression of stress-responsive genes under stress conditions, thereby promoting increased tolerance to drought and salt stresses.
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