ArticlePloS one2015
Tissue-Specific Evolution of Protein Coding Genes in Human and Mouse.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 68 citations in OpenAlex.
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- Why recombination hotspots?PLoS genetics · 2026Review
- Predictors of Protein Evolution in the drosophilid Immune System.Genome biology and evolution · 2026Article
- Under the Shadow: Old-biased Genes Are Subject to Weak Purifying Selection at Both the Tissue- and Cell Type-Specific Levels.Genome biology and evolution · 2025Article
- Gene regulatory networks and essential transcription factors for de novo-originated genes.Nature ecology & evolution · 2025Article
- Evolution and genetics of accessory gland transcriptome divergence between Drosophila melanogaster and D. simulans.Genetics · 2024Article
- Sexual conflict, heterochrony and tissue specificity as evolutionary problems of adaptive plasticity in development.Proceedings. Biological sciences · 2023Review
- Strong Purifying Selection in Haploid Tissue-Specific Genes of Scots Pine Supports the Masking Theory.Molecular biology and evolution · 2023Article
- Robust and rigorous identification of tissue-specific genes by statistically extending tau score.BioData mining · 2022Article
- Dominant transcript expression profiles of human protein-coding genes interrogated with GTEx dataset.Scientific reports · 2022Article
- m6A Topological Transition Coupled to Developmental Regulation of Gene Expression During Mammalian Tissue Development.Frontiers in cell and developmental biology · 2022Article
- Multi-Omics Approaches Revealed the Associations of Host Metabolism and Gut Microbiome With Phylogeny and Environmental Adaptation in Mountain Dragons.Frontiers in microbiology · 2022Article
- Top-ranked expressed gene transcripts of human protein-coding genes investigated with GTEx dataset.Scientific reports · 2020Article
- Enhancers Facilitate the Birth of De Novo Genes and Gene Integration into Regulatory Networks.Molecular biology and evolution · 2020Article
- Transcriptional adaptation ineLife · 2020Article
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- Signatures of Recent Positive Selection in Enhancers Across 41 Human Tissues.G3 (Bethesda, Md.) · 2019Article
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Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein-coding genes evolve at different rates, and the influence of different parameters, from gene size to expression level, has been extensively studied. While in yeast gene expression level is the major causal factor of gene evolutionary rate, the situation is more complex in animals. Here we investigate these relations further, especially taking in account gene expression in different organs as well as indirect correlations between parameters. We used RNA-seq data from two large datasets, covering 22 mouse tissues and 27 human tissues. Over all tissues, evolutionary rate only correlates weakly with levels and breadth of expression. The strongest explanatory factors of purifying selection are GC content, expression in many developmental stages, and expression in brain tissues. While the main component of evolutionary rate is purifying selection, we also find tissue-specific patterns for sites under neutral evolution and for positive selection. We observe fast evolution of genes expressed in testis, but also in other tissues, notably liver, which are explained by weak purifying selection rather than by positive selection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.