Evidence map›Paper›PMID 26121321›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2015

Development of a High-Throughput Functional Screen Using Nanowell-Assisted Cell Patterning.

Ayca Yalcin Ozkumur, Brittany A Goods, J Christopher Love

Abstract read
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ayca Yalcin OzkumurElectrical and Electronics Engineering Department, Bahcesehir University, Istanbul, 34349, Turkey.
Brittany A GoodsDepartment of Biological Engineering, Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA, 02139, USA.
J Christopher LoveDepartment of Chemical Engineering, Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA, 02139, USA.

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MATTHEW G. VANDER HEIDEN · 1985 to 2026
$93.9M
Viral correlates of neutralizing antibody responseU19AI090970 · NIAID · INTERNATIONAL AIDS VACCINE INITIATIVE · PI POIGNARD, PASCAL · 2010 to 2014
$9.3M
NCI NIH HHS P30 CA014051NCI NIH HHS P30-CA14051NIAID NIH HHS U19 AI090970PHS HHS 5 U19 A1090970
6 · The paper itself

Abstract

Living-cell-based screens can facilitate lead discovery of functional therapeutics of interest. A versatile and scalable method is reported that uses dense arrays of nanowells for imparting defined patterns on monolayers of cells. It is shown that this approach can coordinate a multi-component biological assay by designing and implementing a high-throughput, functional nanoliter-scale neutralization assay to identify neutralizing antibodies against HIV.

Indexed as

Drug DesignAnimalsAntibodies, NeutralizingAnti-HIV AgentsBiological ProductsCell MovementCell ProliferationCHO CellsCricetinaeCricetulusFalse Positive ReactionsHigh-Throughput Screening AssaysHIV-1HIV AntibodiesHIV InfectionsHumansAntibodies, NeutralizingAnti-HIV AgentsBiological ProductsHIV Antibodiescell patterninghuman immunodeficiency virus (HIV)living-cell arraysneutralization

Identifiers

PMID26121321
PMCPMC4754792

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.