ArticleThe Pediatric infectious disease journal2015
Respiratory Viral Detections During Symptomatic and Asymptomatic Periods in Young Andean Children.
Article in The Pediatric infectious disease journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
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- Viruses associated with acute respiratory infection in a community-based cohort of healthy New Zealand children.Journal of medical virology · 2022Article
- Assessing the Impact of Acute Respiratory Illnesses on the Risk of Subsequent Respiratory Illness.The Journal of infectious diseases · 2022Article
- Epidemiology and Seasonality of Childhood Respiratory Syncytial Virus Infections in the Tropics.Viruses · 2021Review
- Clinical features of parainfluenza infections among young children hospitalized for acute respiratory illness in Amman, Jordan.BMC infectious diseases · 2021Article
- Virus Coinfection is a Predictor of Radiologically Confirmed Pneumonia in Children with Bordetella pertussis Infection.Infectious diseases and therapy · 2021Article
- Nasopharyngeal Pneumococcal Density during Asymptomatic Respiratory Virus Infection and Risk for Subsequent Acute Respiratory Illness.Emerging infectious diseases · 2019Article
- Reassessment of high prevalence human adenovirus detections among residents of two refugee centers in Kenya under surveillance for acute respiratory infections.Journal of medical virology · 2019Article
- Human adenovirus in nasopharyngeal and blood samples from children with and without respiratory tract infections.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2019Article
- Viruses causing lower respiratory symptoms in young children: findings from the ORChID birth cohort.Thorax · 2018Observational
- A novel real-time RT-PCR assay for influenza C tested in Peruvian children.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2017Article
- Nasopharyngeal Pneumococcal Density Is Associated With Viral Activity but Not With Use of Improved Stoves Among Young Andean Children.Open forum infectious diseases · 2017Article
- Etiology of severe pneumonia in Ecuadorian children.PloS one · 2017Observational
- Spatial and Temporal Spread of Acute Viral Respiratory Infections in Young Children Living in High-altitude Rural Communities: A Prospective Household-based Study.The Pediatric infectious disease journal · 2016Article
- Molecular Epidemiology of Rhinovirus Detections in Young Children.Open forum infectious diseases · 2016Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundViruses are commonly detected in children with acute respiratory illnesses (ARIs) and in asymptomatic children. Longitudinal studies of viral detections during asymptomatic periods surrounding ARI could facilitate interpretation of viral detections but are currently scant.
methodsWe used reverse transcription polymerase chain reaction to analyze respiratory samples from young Andean children for viruses during asymptomatic periods within 8-120 days of index ARI (cough or fever). We compared viral detections over time within children and explored reverse transcription polymerase chain reaction cycle thresholds (CTs) as surrogates for viral loads.
resultsAt least 1 respiratory virus was detected in 367 (43%) of 859 samples collected during asymptomatic periods, with more frequent detections in periods with rhinorrhea (49%) than those without (34%, P < 0.001). Relative to index ARI with human rhinovirus (HRV), adenovirus (AdV), respiratory syncytial virus (RSV) and parainfluenza virus detected, the same viruses were also detected during 32, 22, 10 and 3% of asymptomatic periods, respectively. RSV was only detected 8-30 days after index RSV ARI, whereas HRV and AdV were detected throughout asymptomatic periods. Human metapneumovirus and influenza were rarely detected during asymptomatic periods (<3%). No significant differences were observed in the CT for HRV or AdV during asymptomatic periods relative to ARI. For RSV, CTs were significantly lower during ARI relative to the asymptomatic period (P = 0.03).
conclusionsThese findings indicate that influenza, human metapneumovirus, parainfluenza virus and RSV detections in children with an ARI usually indicate a causal relationship. When HRV or AdV is detected during ARI, the causal relationship is less certain.
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