ReviewNature medicine2015
Influence of nutrient-derived metabolites on lymphocyte immunity.
Review in Nature medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 123 citations in OpenAlex.
- Insulin-sensitizing effects of vitamin D repletion mediated by adipocyte vitamin D receptor: Studies in humans and mice.Molecular metabolism · 2020Trial
- Effects of water quality, sanitation, handwashing, and nutritional interventions on diarrhoea and child growth in rural Bangladesh: a cluster randomised controlled trial.The Lancet. Global health · 2018Trial
- Metabolomic Signatures of Relapse and Survival in AML Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation.Hematology reports · 2026Article
- Metabolomic profiling reveals the potential of fatty acids as regulators of exhausted CD8 T cells during chronic viral infection.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Aryl Hydrocarbon Receptor Activation Promotes Effector CD4+ T Cell Homeostasis and Restrains Salt-Sensitive Hypertension.Function (Oxford, England) · 2025Article
- The role of controlling nutritional status score in predicting postthrombotic syndrome in patients with lower extremity deep venous thrombosis.Thrombosis journal · 2025Article
- Genome-wide association study of maternal plasma metabolites during pregnancy.Cell genomics · 2024Article
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- Immunological factors linked to geographical variation in vaccine responses.Nature reviews. Immunology · 2024Review
- Characterization of Bovine Intraepithelial T Lymphocytes in the Gut.Pathogens (Basel, Switzerland) · 2023Article
- Metabolomics in asthma: A platform for discovery.Molecular aspects of medicine · 2022Review
- Factors Associated with Malnutrition and Its Impact on Postoperative Outcomes in Older Patients.Journal of clinical medicine · 2021Article
- Butyrate and the Fine-Tuning of Colonic Homeostasis: Implication for Inflammatory Bowel Diseases.International journal of molecular sciences · 2021Review
- Impact of Bacterial Metabolites on Gut Barrier Function and Host Immunity: A Focus on Bacterial Metabolism and Its Relevance for Intestinal Inflammation.Frontiers in immunology · 2021Review
- The Wanderings of Gut-Derived IgA Plasma Cells: Impact on Systemic Immune Responses.Frontiers in immunology · 2021Review
- B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids.Nature communications · 2020Article
- Metabolic Regulation of Group 3 Innate Lymphoid Cells and Their Role in Inflammatory Bowel Disease.Frontiers in immunology · 2020Review
- Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites.Nature communications · 2019Article
- Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology.Nature communications · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Organisms need to protect themselves against potential dangers from their surroundings, yet they require constant and intimate interactions with the same environment for their survival. The immune system is instrumental for protection against invading organisms and their toxins. The immune system consists of many cell types and is highly integrated within other tissues. Immune activity is particularly enriched at surfaces that separate the host from its environment, such as the skin and the gastrointestinal tract. This enables protection at sites directly at risk but also enables environmental factors to influence the maturation and function of immune structures and cells. Recent work has indicated that the diet in particular is able to influence the immune system and thus affect the development of inflammatory disease. This review aims to highlight recent work on how external factors, with a focus on those derived from the diet such as vitamin A, can have a direct or indirect deterministic influence on the activity and function of immunity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.