ArticlePloS one2015
Genome-Wide Association Analysis for Blood Lipid Traits Measured in Three Pig Populations Reveals a Substantial Level of Genetic Heterogeneity.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Functional genomic dissection and prediction of body size traits in pigs.Genetics, selection, evolution : GSE · 2026Article
- Pleiotropic genetic association analysis with multiple phenotypes using multivariate response best-subset selection.BMC genomics · 2023Article
- A maximum kernel-based association test to detect the pleiotropic genetic effects on multiple phenotypes.Bioinformatics (Oxford, England) · 2023Article
- Genome-Wide Detection of Runs of Homozygosity in Laiwu Pigs Revealed by Sequencing Data.Frontiers in genetics · 2021Article
- Genome-wide association analyses identify known and novel loci for teat number in Duroc pigs using single-locus and multi-locus models.BMC genomics · 2020Article
- A Genome-Wide Association Study Identifies Quantitative Trait Loci Affecting Hematological Traits inAnimals : an open access journal from MDPI · 2020Article
- Genome-wide scan reveals genetic divergence and diverse adaptive selection in Chinese local cattle.BMC genomics · 2019Article
- Genome-wide association studies for 30 haematological and blood clinical-biochemical traits in Large White pigs reveal genomic regions affecting intermediate phenotypes.Scientific reports · 2019Article
- Evaluating the contribution of gut microbiome to the variance of porcine serum glucose and lipid concentration.Scientific reports · 2017Article
- Dynamic transcriptome and DNA methylome analyses on longissimus dorsi to identify genes underlying intramuscular fat content in pigs.BMC genomics · 2017Article
- Joint QTL mapping and gene expression analysis identify positional candidate genes influencing pork quality traits.Scientific reports · 2017Article
- Haplotypes on pig chromosome 3 distinguish metabolically healthy from unhealthy obese individuals.PloS one · 2017Article
- Genetic determinants of pig birth weight variability.BMC genetics · 2016Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serum lipids are associated with myocardial infarction and cardiovascular disease in humans. Here we dissected the genetic architecture of blood lipid traits by applying genome-wide association studies (GWAS) in 1,256 pigs from Laiwu, Erhualian and Duroc × (Landrace × Yorkshire) populations, and a meta-analysis of GWAS in more than 2,400 pigs from five diverse populations. A total of 22 genomic loci surpassing the suggestive significance level were detected on 11 pig chromosomes (SSC) for six blood lipid traits. Meta-analysis of GWAS identified 5 novel loci associated with blood lipid traits. Comparison of GWAS loci across the tested populations revealed a substantial level of genetic heterogeneity for porcine blood lipid levels. We further evaluated the causality of nine polymorphisms nearby or within the APOB gene on SSC3 for serum LDL-C and TC levels. Of the 9 polymorphisms, an indel showed the most significant association with LDL-C and TC in Laiwu pigs. But the significant association was not identified in the White Duroc × Erhualian F2 resource population, in which the QTL for LDL-C and TC was also detected on SSC3. This indicates that population-specific signals may exist for the SSC3 QTL. Further investigations are warranted to validate this assumption.
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