Evidence map›Paper›PMID 26121049›Full record

ArticleChemical communications (Cambridge, England)2015

Selective targeting of Mycobacterium smegmatis with trehalose-functionalized nanoparticles.

Kalana W Jayawardana, H Surangi N Jayawardena, Samurdhi A Wijesundera, Thareendra De Zoysa, Madanodaya Sundhoro, Mingdi Yan

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
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  17. Article
  18. Glyconanomaterials for biosensing applications.Biosensors & bioelectronics · 2016
    Review
  19. Article
  20. Glyconanomaterials for Combating Bacterial Infections.Chemistry (Weinheim an der Bergstrasse, Germany) · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kalana W JayawardanaDepartment of Chemistry, University of Massachusetts Lowell, Lowell, MA 01854, USA. mingdi_yan@uml.edu.
H Surangi N Jayawardena
Samurdhi A Wijesundera
Thareendra De Zoysa
Madanodaya Sundhoro
Mingdi Yan
University of Massachusetts Lowell · USMassachusetts Institute of Technology · US

Funding

Photogenerated Carbohydrate MicroarraysR01GM080295 · NIGMS · UNIVERSITY OF MASSACHUSETTS LOWELL · PI YAN, MINGDI · 2008 to 2012
$2.0M
Maltoheptaose based nanotherapeutics for multidrug resistant bacterial infectionR21AI109896 · NIAID · UNIVERSITY OF MASSACHUSETTS LOWELL · PI YAN, MINGDI · 2014 to 2015
$444k
NIAID NIH HHS R21 AI109896NIGMS NIH HHS R01 GM080295
6 · The paper itself

Abstract

Silica and iron oxide nanoparticles with sizes ranging from 6 to 40 nm were functionalized with trehalose. The trehalose-conjugated nanoparticles showed strong interactions with Mycobacterium smegmatis (M. smegmatis) and minimal interactions with macrophage (RAW 264.7) or A549 cells. In addition, trehalose-conjugated silica nanoparticles selectively interacted with M. smegmatis on M. smegmatis-treated A549 cells, demonstrating high potential of trehalose in developing targeted therapy for treating mycobacterial infection.

Indexed as

AnimalsCell LineHumansMiceMolecular Targeted TherapyMycobacterium Infections, NontuberculousMycobacterium smegmatisNanoparticlesTrehaloseTrehalose

Identifiers

PMID26121049
PMCPMC4503493
OpenAlexW1888556913

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.