Evidence map›Paper›PMID 26121035›Full record

ArticlePloS one2015

Sex Differences in Biological Markers of Health in the Study of Stress, Aging and Health in Russia.

Anna Oksuzyan, Maria Shkolnikova, James W Vaupel, Kaare Christensen, Vladimir M Shkolnikov

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Population norms of health-related quality of life in Moscow, Russia: the EQ-5D-5L-based survey.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021
    Article
  6. Article
  7. Article
  8. Gender Differences in Biological Function in Young Adulthood: An Intragenerational Perspective.The Russell Sage Foundation journal of the social sciences : RSF · 2018
    Article
  9. Men Sustain Higher Dysregulation Levels Than Women Without Becoming Frail.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Anna OksuzyanMax Planck Institute for Demographic Research, Rostock, Germany; Department of Epidemiology, Biostatistics, and Biodemography, University of Southern Denmark, Odense, Denmark.
Maria ShkolnikovaScientific and Clinical Institute of Pediatry at the Pirogov Moscow Medical University, Moscow, Russian Federation.
James W VaupelMax Planck Institute for Demographic Research, Rostock, Germany; Max-Planck Odense Center on the Biodemography of Aging, Odense, Denmark.
Kaare ChristensenDepartment of Epidemiology, Biostatistics, and Biodemography, University of Southern Denmark, Odense, Denmark; Max-Planck Odense Center on the Biodemography of Aging, Odense, Denmark; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark; Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.
Vladimir M ShkolnikovMax Planck Institute for Demographic Research, Rostock, Germany; New Economic School, Moscow, Russian Federation.
Max Planck Institute for Demographic Research · DEOdense University Hospital · DKPirogov Russian National Research Medical University · RU

Funding

STALLARD Admin Supp: Predicting Future Care Needs and Costs for Individual Medicare Enrollees with Incident Suspected Alzheimer's DiseaseP30AG034424 · NIA · DUKE UNIVERSITY · PI SCOTT M. LYNCH · 2009 to 2026
$12.2M
THE RANGE OF MALE-FEMALE MORTALITY DIFFERENCESP01AG031719 · NIA · DUKE UNIVERSITY · PI ZENG, YI · 2009 to 2020
$10.2M
Biodemography of Disease and Death in MoscowR01AG026786 · NIA · DUKE UNIVERSITY · PI VAUPEL, JAMES W. · 2006 to 2010
$1.9M
NIA NIH HHS P01 AG031719NIA NIH HHS P01AG031719NIA NIH HHS P30 AG034424NIA NIH HHS R01 AG026786NIA NIH HHS R01AG026786
6 · The paper itself

Abstract

backgroundThe apparent contradiction that women live longer but have worse health than men, the so called male-female health-survival paradox, is very pronounced in Russia. The present study investigates whether men in Moscow are healthier than women at the level of biomarkers, and whether the associations between biomarkers and subjective health have sex-specific patterns. MATERIALS: Previously collected data in the study of Stress, Aging, and Health in Russia (SAHR, n = 1800) were used to examine sex differences in biomarkers and their associations with physical functioning and self-rated health.

resultsThe present study found mixed directions and magnitudes for sex differences in biomarkers. Women were significantly disadvantaged with regard to obesity and waist circumference, whereas men had a tendency toward higher prevalence of electrocardiographic abnormalities. No sex differences were indicated in the prevalence of immunological biomarkers, and mixed patterns were found for lipid profiles. Many biomarkers were associated with physical functioning and general health. Obesity and waist circumference were related to lower physical functioning among females only, while major Q-wave abnormalities with high probabilities of myocardial infarction and atrial fibrillation or atrial flutter were associated with physical functioning and self-rated health among males only.

conclusionNo clear patterns of sex differences in prevalence of high-risk levels of biomarkers suggest that the male-female health-survival paradox is weaker at the level of health biomarkers. We found some evidence that certain biomarkers reflecting pathophysiological changes in the organism that do not possess acute health risks, but over many years may lead to physical disability, are associated with physical functioning and self-rated health in women, whereas others reflecting more serious life-threatening pathophysiological changes are associated with physical functioning and self-rated health in men.

Indexed as

HealthSex CharacteristicsStress, PhysiologicalAgedAgingBiomarkersFemaleHumansMaleRussiaBiomarkers

Identifiers

PMID26121035
PMCPMC4484801
OpenAlexW2102482667

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.