Evidence map›Paper›PMID 26120846›Full record

Trial reportPloS one2015

Determinants and Experiences of Repeat Pregnancy among HIV-Positive Kenyan Women--A Mixed-Methods Analysis.

Victor Akelo, Eleanor McLellan-Lemal, Lauren Toledo, Sonali Girde, Craig B Borkowf, Laura Ward, Kenneth Ondenge, Richard Ndivo, Shirley L Lecher, Lisa A Mills and 1 more

Erratum issuedOpen access · goldAbstract readClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Victor AkeloKenya Medical Research Institute, Kisumu, Kenya.
Eleanor McLellan-LemalCenters for Disease Control and Prevention, Atlanta, GA, United States of America.
Lauren ToledoCenters for Disease Control and Prevention, Atlanta, GA, United States of America; ICF International, Atlanta, GA, United States of America.
Sonali GirdeCenters for Disease Control and Prevention, Atlanta, GA, United States of America; ICF International, Atlanta, GA, United States of America.
Craig B BorkowfCenters for Disease Control and Prevention, Atlanta, GA, United States of America.
Laura WardRollins School of Public Health, Emory University, Atlanta, GA, United States of America.
Kenneth OndengeKenya Medical Research Institute, Kisumu, Kenya.
Richard NdivoKenya Medical Research Institute, Kisumu, Kenya.
Shirley L LecherCenters for Disease Control and Prevention, Atlanta, GA, United States of America.
Lisa A MillsRollins School of Public Health, Emory University, Atlanta, GA, United States of America.
Timothy K ThomasCenters for Disease Control and Prevention, Kisumu, Kenya.
Centers for Disease Control and Prevention · USKenya Medical Research Institute · KEEmory University · USCenters for Disease Control and Prevention · KEICF International (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo identify factors associated with repeat pregnancy subsequent to an index pregnancy among women living with HIV (WLWH) in western Kenya who were enrolled in a 24-month phase-II clinical trial of triple-ART prophylaxis for prevention of mother-to-child transmission, and to contextualize social and cultural influences on WLWH's reproductive decision making.

methodsA mixed-methods approach was used to examine repeat pregnancy within a 24 month period after birth. Counselor-administered questionnaires were collected from 500 WLWH. Forty women (22 with a repeat pregnancy; 18 with no repeat pregnancy) were purposively selected for a qualitative interview (QI). Simple and multiple logistic regression analyses were performed for quantitative data. Thematic coding and saliency analysis were undertaken for qualitative data.

resultsEighty-eight (17.6%) women had a repeat pregnancy. Median maternal age was 23 years (range 15-43 years) and median gestational age at enrollment was 34 weeks. In multiple logistic regression analyses, living in the same compound with a husband (adjusted odds ratio (AOR): 2.33; 95% confidence interval (CI): 1.14, 4.75) was associated with increased odds of repeat pregnancy (p ≤ 0.05). Being in the 30-43 age group (AOR: 0.25; 95% CI: 0.07, 0.87), having talked to a partner about family planning (FP) use (AOR: 0.53; 95% CI: 0.29, 0.98), and prior usage of FP (AOR: 0.45; 95% CI: 0.25, 0.82) were associated with a decrease in odds of repeat pregnancy. QI findings centered on concerns about modern contraception methods (side effects and views that they 'ruined the womb') and a desire to have the right number of children. Religious leaders, family, and the broader community were viewed as reinforcing cultural expectations for married women to have children. Repeat pregnancy was commonly attributed to contraception failure or to lack of knowledge about post-delivery fertility.

conclusionsIn addition to cultural context, reproductive health programs for WLWH may need to address issues related to living circumstances and the possibility that reproductive-decision making may extend beyond the woman and her partner.

Indexed as

AdolescentAdultBreast FeedingFemaleHIV InfectionsHumansKenyaMultivariate AnalysisPregnancyYoung Adult

Identifiers

PMID26120846
PMCPMC4488283
OpenAlexW1878858932

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.