ArticleInternational journal of stroke : official journal of the International Stroke Society2015
A comparison of location of acute symptomatic vs. 'silent' small vessel lesions.
Article in International journal of stroke : official journal of the International Stroke Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 67 citations in OpenAlex.
- Observational
- Clinical Relevance of 'Cap' and 'Track' Development after Recent Small Subcortical Infarct.Annals of neurology · 2025Article
- Small vessel disease contributions to acute delirium: a pilot feasibility MRI study.Age and ageing · 2025Article
- Modulatory Effects of Hypertension on Aging-Related White Matter Hyperintensities: A Comparative Study Among Stroke Patients and Stroke-Free Community-Based Cohort.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Atherogenic and Inflammatory Markers in Recent Small Subcortical Infarcts: Associations with Location, Morphology, and Short-Term Recurrence.Journal of inflammation research · 2025Article
- Incident Infarcts in Patients With Stroke and Cerebral Small Vessel Disease: Frequency and Relation to Clinical Outcomes.Neurology · 2024Article
- Ischemic stroke recurrence and mortality in different imaging phenotypes of ischemic cerebrovascular disease: The SMART-MR Study.European stroke journal · 2023Article
- Examining temporal features of BOLD-based cerebrovascular reactivity in clinical populations.Frontiers in neurology · 2023Article
- Regional Cerebral Small Vessel Disease (rCSVD) Score: A clinical MRI grading system validated in a stroke cohort.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2022Article
- Distribution Pattern Analysis of Cortical Brain Infarcts on Diffusion-Weighted Magnetic Resonance Imaging: A Hypothesis-Generating Approach to the Burden of Silent Embolic Stroke.Journal of the American Heart Association · 2022Article
- Prevalence and Significance of the Vessel-Cluster Sign on Susceptibility-Weighted Imaging in Patients With Severe Small Vessel Disease.Neurology · 2022Observational
- The Potential Impact of Neuroimaging and Translational Research on the Clinical Management of Lacunar Stroke.International journal of molecular sciences · 2022Review
- Brain network reorganisation and spatial lesion distribution in systemic lupus erythematosus.Lupus · 2021Article
- Lacunar Stroke Lesion Extent and Location and White Matter Hyperintensities Evolution 1 Year Post-lacunar Stroke.Frontiers in neurology · 2021Article
- Post-stroke Cognition at 1 and 3 Years Is Influenced by the Location of White Matter Hyperintensities in Patients With Lacunar Stroke.Frontiers in neurology · 2021Article
- Clinical management of cerebral small vessel disease: a call for a holistic approach.Chinese medical journal · 2020Review
- Extent and characteristics of carotid plaques and brain parenchymal loss in asymptomatic patients with no indication for revascularization.International journal of cardiology. Heart & vasculature · 2020Article
- Symptoms and probabilistic anatomical mapping of lacunar infarcts.Neurological research and practice · 2020Article
- Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration.Alzheimer's & dementia (Amsterdam, Netherlands) · 2019Review
- Cerebral small vessel disease: neuroimaging markers and clinical implication.Journal of neurology · 2019Review
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAcute lacunar ischaemic stroke, white matter hyperintensities, and lacunes are all features of cerebral small vessel disease. It is unclear why some small vessel disease lesions present with acute stroke symptoms, whereas others typically do not.
aimTo test if lesion location could be one reason why some small vessel disease lesions present with acute stroke, whereas others accumulate covertly.
methodsWe identified prospectively patients who presented with acute lacunar stroke symptoms with a recent small subcortical infarct confirmed on magnetic resonance diffusion imaging. We compared the distribution of the acute infarcts with that of white matter hyperintensity and lacunes using computational image mapping methods.
resultsIn 188 patients, mean age 67 ± standard deviation 12 years, the lesions that presented with acute lacunar ischaemic stroke were located in or near the main motor and sensory tracts in (descending order): posterior limb of the internal capsule (probability density 0·2/mm(3)), centrum semiovale (probability density = 0·15/mm(3)), medial lentiform nucleus/lateral thalamus (probability density = 0·09/mm(3)), and pons (probability density = 0·02/mm(3)). Most lacunes were in the lentiform nucleus (probability density = 0·01-0·04/mm(3) ) or external capsule (probability density = 0·05/mm(3)). Most white matter hyperintensities were in centrum semiovale (except for the area affected by the acute symptomatic infarcts), external capsules, basal ganglia, and brainstem, with little overlap with the acute symptomatic infarcts (analysis of variance, P < 0·01).
conclusionsLesions that present with acute lacunar ischaemic stroke symptoms may be more likely noticed by the patient through affecting the main motor and sensory tracts, whereas white matter hyperintensity and asymptomatic lacunes mainly affect other areas. Brain location could at least partly explain the symptomatic vs. covert development of small vessel disease.
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