Evidence map›Paper›PMID 26120559›Full record

ArticleMolecular genetics and metabolism reports2015

Physiological Competition of Brain Phenylalanine Accretion: Initial Pharmacokinetic Analyses of Aminoisobutyric and Methylaminoisobutyric Acids in

Kara R Vogel, Garrett R Ainslie, Brian Phillips, Erland Arning, Teodoro Bottiglieri, Danny D Shen, K Michael Gibson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics and metabolism reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kara R VogelSection of Experimental and Systems Pharmacology, College of Pharmacy, Washington State University, Spokane, WA.
Garrett R AinslieSection of Experimental and Systems Pharmacology, College of Pharmacy, Washington State University, Spokane, WA.
Brian PhillipsDepartments of Pharmaceutics and Pharmacy, University of Washington School of Pharmacy, Seattle, WA.
Erland ArningInstitute for Metabolic Disease, Baylor Research Institute, Dallas, TX.
Teodoro BottiglieriInstitute for Metabolic Disease, Baylor Research Institute, Dallas, TX.
Danny D ShenDepartments of Pharmaceutics and Pharmacy, University of Washington School of Pharmacy, Seattle, WA.
K Michael GibsonSection of Experimental and Systems Pharmacology, College of Pharmacy, Washington State University, Spokane, WA.
Washington State University Spokane · USResearch Institute of Dallas · USUniversity of Washington · US

Funding

Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0M
Institute of Translational Health SciencesUL1TR000423 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$49.4M
Therapeutics of mTOR Signaling in Succinic Semialdehyde Dehydrogenase DeficiencyR21NS085369 · NINDS · WASHINGTON STATE UNIVERSITY · PI GIBSON, K MICHAEL · 2014 to 2015
$432k
NCATS NIH HHS UL1 TR000423NCATS NIH HHS UL1 TR002319NINDS NIH HHS R21 NS085369
6 · The paper itself

Abstract

objectiveInitial studies on the use of non-physiological amino acids (NPAAs) to block the accretion of Phe in the brain

methodsControl and

resultsMAIB was partially converted to AIB

conclusionsOur data support further pharmacokinetic characterization of MAIB and AIB in preparation for further preclinical safety, toxicity and tolerability studies of both AIB and MAIB.

Indexed as

Aminoisobutyric AcidLarge Neutral Amino AcidsLAT-1 TransporterMethylaminoisobutyric AcidPharmacokineticsPhenylalaninePhenylketonuria

Identifiers

PMID26120559
PMCPMC4478616
OpenAlexW1597473604

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.