ReviewAllergo journal international
Clinical and diagnostic challenges of metal implant allergy using the example of orthopaedic surgical implants: Part 15 of the Series Molecular Allergology.
Review in Allergo journal international. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Suspected Hypersensitivity Reaction to Titanium Screws Following Kalish Osteotomy for Hallux Valgus.Cureus · 2026Article
- Allergic Reaction to Titanium Alloy Osteosynthesis Implants: A Case Report of Three Patients.Life (Basel, Switzerland) · 2026Article
- Titanium Cable Cerclage Increases the Load to Failure in Plate Osteosynthesis for Distal Femoral Fractures.Medicina (Kaunas, Lithuania) · 2024Article
- Are Allergy-Induced Implant Failures Actually Hypersensitivity Reactions to Titanium? A Literature Review.Dentistry journal · 2023Review
- Hyaluronic acid-British anti-Lewisite as a safer chelation therapy for the treatment of arthroplasty-related metallosis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Hypersensitivity Reactions to Components of Cardiac Implantable Electronic Devices and Their Treatment: A Systematic Review.Arrhythmia & electrophysiology review · 2023Review
- Fatigue Crack Growth and Fracture of Internal Fixation Materials in In Vivo Environments-A Review.Materials (Basel, Switzerland) · 2021Review
- Nickel allergy to orthopaedic implants: A review and case series.Journal of clinical orthopaedics and trauma · 2020Review
- Incidence of Metal Hypersensitivity in Orthopedic Surgical Patients Who Self-Report Hypersensitivity History.The Permanente journal · 2020Article
- Neuropathy Caused by Metal Hypersensitivity after Placement of Stainless Steel Plate.Case reports in orthopedics · 2020Article
- A case series of cementless revision total knee arthroplasty in patients with benzoyl peroxide allergy.International orthopaedics · 2019Article
- Exploring the Incidence, Implications, and Relevance of Metal Allergy to Orthopaedic Surgeons.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2019Article
- Long-term outcome after implantation of a nickel-containing cemented hip stem on the right in a patient with type IV sensitization to nickel sulphate.GMS Interdisciplinary plastic and reconstructive surgery DGPW · 2019Article
- TCM treatment of allergy induced by stainless steel implants for tibiofibular fracture: A case report.Allergologie select · 2019Article
- Skin Complications of Orthopedic Procedures and Devices.Iranian journal of public health · 2018Article
- [Pseudo allergic reaction to metal implant].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2018Article
- Hard Chrome-Coated and Fullerene-Doped Metal Surfaces in Orthopedic Bearings.Materials (Basel, Switzerland) · 2017Article
- Systemic contact dermatitis to a surgical implant presenting as red decorative tattoo reaction.JAAD case reports · 2017Article
- Hypersensitivity to Orthopedic Implants: A Review of the Literature.Rheumatology and therapy · 2017Review
- [Compatibility and allergies of osteosynthesis materials].Der Unfallchirurg · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The focus of this review are allergic reactions to orthopaedic-surgical metal implants. The spectrum of metal implant associated potential allergic reactions encompasses eczema, impaired wound and fracture healing, infection-mimicking reactions, effusions, pain and loosening. Nickel, cobalt and chromium seem to be the predominant eliciting allergens. Despite the growing number of respective publications the topic "metal implant allergy" remains a diagnostic challenge. Initially, differential diagnoses should always be excluded in cooperation with surgery collegues. It is recommended to perform a combined evaluation of medical history, clinical findings, patch testing and histology. The lymphocyte transformation test (LTT) can indicate metal sensitization, but it needs careful interpretation. Allergists can provide a substantial contribution to this interdisciplinary topic.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.