ReviewAllergo journal international
Human heart as a shock organ in anaphylaxis.
Review in Allergo journal international. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Protocols for Diagnosis and Management of Arthropod Bite Allergies in Humans.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Kounis Syndrome in the Modern Era: A Comprehensive Review of Allergic Acute Coronary Syndromes.Journal of clinical medicine · 2026Review
- Adrenaline, Takotsubo Cardiomyopathy, Anaphylaxis, and Kounis Syndrome (ATAK) Complex: Clinical Phenotypes, Differential Diagnosis, and Management.JACC. Case reports · 2026Article
- Mast Cells at the Crossroads of Hypersensitivity Reactions and Neurogenic Inflammation.International journal of molecular sciences · 2025Review
- Antigenicity evaluation of lac color and exploratory study for identifying potential biomarkers of anaphylaxis.Laboratory animal research · 2024Article
- NButGT Reinforces the Beneficial Effects of Epinephrine on Cardiac Mitochondrial Respiration, Lactatemia and Cardiac Output in Experimental Anaphylactic Shock.International journal of molecular sciences · 2024Article
- Mast cell-mediated immune regulation in health and disease.Frontiers in medicine · 2023Review
- Identification of the biological processes, immune cell landscape, and hub genes shared by acute anaphylaxis and ST-segment elevation myocardial infarction.Frontiers in pharmacology · 2023Article
- Histamine receptors in heart failure.Heart failure reviews · 2022Review
- Impaired Myocardial Mitochondrial Function in an Experimental Model of Anaphylactic Shock.Biology · 2022Article
- Pathophysiological, Cellular, and Molecular Events of the Vascular System in Anaphylaxis.Frontiers in immunology · 2022Review
- The Roles of Cardiovascular HFrontiers in pharmacology · 2021Review
- Kounis Syndrome Secondary to Medicine-Induced Hypersensitivity.Case reports in medicine · 2021Article
- Anaphylactoid Reaction from Trimethoprim-Sulfamethoxazole with Subsequent T-wave Inversions in a Young Patient with Dermatomyositis.The Journal of clinical and aesthetic dermatology · 2019Article
- Substance P-mediated cardiac mast cell activation: An in vitro study.Neuropeptides · 2019Article
- Cellular and Immunohistochemical Changes in Anaphylactic Shock Induced in the Ovalbumin-Sensitized Wistar Rat Model.Biomolecules · 2019Article
- Anaphylactic cardiovascular collapse and Kounis syndrome: systemic vasodilation or coronary vasoconstriction?Annals of translational medicine · 2018Review
- Drug induced Kounis syndrome: does oxidative stress play a role?Clinical and molecular allergy : CMA · 2018Article
- Skin to Intramuscular Compartment Thigh Measurement by Ultrasound in Pediatric Population.The western journal of emergency medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anaphylaxis is a potentially fatal, immediate hypersensitivity reaction. Mast cells and basophils, by elaborating vasoactive mediators and cytokines, are the main primary effector cells of anaphylaxis. Mast cells have been identified in human heart between myocardial fibers, perivascularly, in the adventitia, and in the arterial intima. Mast cells isolated from human heart tissue (HHMC) of patients undergoing cardiac transplantation express high affinity immunglobulin E (IgE) receptors (FcεRI), C3a, C5a, and kit receptors (KIT). Anti-IgE, anti-FcεRI, and immunoglobulin superallergens induce in vitro secretion of preformed mediators (histamine, tryptase, chymase, and renin) and the de novo synthesis of cysteinyl leukotriene C4 (LTC4) and prostaglandin D2 (PGD2) from HHMC. Complement is activated and anaphylatoxin forms during anaphylaxis. C5a and C3a cause the in vitro release of histamine and tryptase from HHMC. Therapeutic (general anesthetics, protamine, etc.) and diagnostic agents (radio contrast media, etc.), which can cause anaphylactoid reactions, activate HHMC in vitro. Low concentrations of histamine and cysteinyl leukotrienes given to subjects undergoing diagnostic catheterisation caused significant systemic and coronary hemodynamic effects. These data indicate that human heart mast cells and their mediators play a role in severe anaphylactic reactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.