ArticleCurrent pathobiology reports2015
Kidney Regeneration: Lessons from Development.
Article in Current pathobiology reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- A comparative transcriptomics analysis of mammalian and non-mammalian acute kidney injury (AKI) models.Frontiers in cell and developmental biology · 2025Article
- Pax protein depletion in proximal tubules triggers conserved mechanisms of resistance to acute ischemic kidney injury preventing transition to chronic kidney disease.Kidney international · 2024Article
- Formation of the glomerular microvasculature is regulated by VEGFR-3.American journal of physiology. Renal physiology · 2023Article
- Early activation of fibroblasts is required for kidney repair and regeneration after injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Characterization of kidney CD45intCD11bintF4/80+MHCII+CX3CR1+Ly6C- "intermediate mononuclear phagocytic cells".PloS one · 2018Article
- Hyperactive FOXO1 results in lack of tip stalk identity and deficient microvascular regeneration during kidney injury.Biomaterials · 2017Article
- Does Renal Repair Recapitulate Kidney Development?Journal of the American Society of Nephrology : JASN · 2017Review
- Delayed treatment with PTBA analogs reduces postinjury renal fibrosis after kidney injury.American journal of physiology. Renal physiology · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
A number of genes involved in kidney development are reactivated in the adult after acute kidney injury (AKI). This has led to the belief that tissue repair mechanisms recapitulate pathways involved in embryonic development after AKI. We will discuss evidence to support this hypothesis by comparing the mechanisms of development with common pathways known to regulate post-AKI repair, or that we identified as cell-specific candidates based on public datasets from recent AKI translational profiling studies. We will argue that while many of these developmental pathways are reactivated after AKI, this is not associated with general cellular reprogramming to an embryonic state. We will show that reactivation of these developmental genes is often associated with expression in cells that are not normally involved in mediating parallel responses in the embryo, and that depending on the cellular context, these responses can have beneficial or detrimental effects on injury and repair after AKI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.