Evidence map›Paper›PMID 26120443›Full record

ArticleClinical kidney journal2013

Successful treatment of adult-onset collapsing focal segmental glomerulosclerosis with rituximab.

Raja Ramachandran, Venkatesh Rajakumar, Ritambhra Duseja, Vinay Sakhuja, Vivekanand Jha

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical kidney journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Raja RamachandranDepartment of Nephrology , Postgraduate Institute of Medical Education and Research , Chandigarh , India.
Venkatesh RajakumarDepartment of Nephrology , Postgraduate Institute of Medical Education and Research , Chandigarh , India.
Ritambhra DusejaDepartment of Histopathology , Postgraduate Institute of Medical Education and Research , Chandigarh , India.
Vinay SakhujaDepartment of Nephrology , Postgraduate Institute of Medical Education and Research , Chandigarh , India.
Vivekanand JhaDepartment of Nephrology , Postgraduate Institute of Medical Education and Research , Chandigarh , India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Collapsing focal segmental glomerulosclerosis (FSGS), or collapsing glomerulopathy (CG), responds poorly to commonly employed therapies, with a high proportion of patients progressing to end-stage renal disease. We report an adult in a nephrotic state, diagnosed with minimal-change disease on biopsy, who failed to respond to steroids, calcineurin inhibitors (CNIs), mycophenolate mofetil and cyclophosphamide. Repeat biopsy showed CG. Treatment with 4 weekly doses of rituximab led to sustained remission of his nephrotic state. This is the first report of adult-onset CG that has responded favourably to rituximab. Rituximab could be a treatment option for patients with this difficult-to-treat condition.

Indexed as

collapsing glomerulopathyfocal segmental glomerulosclerosisrituximab

Identifiers

PMID26120443
PMCPMC4438415

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.