Evidence map›Paper›PMID 26120274›Full record

ArticleMolecular vision2015

Vasodilatory mechanisms of unoprostone isopropyl in isolated porcine retinal arterioles.

Ichiro Tanano, Taiji Nagaoka, Shinji Ono, Tsuneaki Omae, Shinichi Otani, Akitoshi Yoshida

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Molecular vision, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ichiro TananoDepartment of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan.
Taiji NagaokaDepartment of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan.
Shinji OnoDepartment of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan.
Tsuneaki OmaeDepartment of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan.
Shinichi OtaniDepartment of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan.
Akitoshi YoshidaDepartment of Ophthalmology, Asahikawa Medical University, Asahikawa, Japan.
Asahikawa Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo clarify the vasodilatory mechanism of unoprostone isopropyl (UI), we examined its effects on the retinal microvascular diameter to determine the dependence on the endothelium and/or smooth muscle to reveal the signaling mechanisms involved in this vasomotor activity.

methodsPorcine retinal arterioles were isolated, cannulated, and pressurized without flow in vitro. Video microscopic techniques recorded the diametric responses to UI.

resultsThe retinal arterioles dilated in response to UI in a dose-dependent (100 pM-10 µM) manner. The nitric oxide (NO) synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) inhibited UI-induced vasodilation. The large-conductance Ca2+-activated K channel (BKCa channel) blocker iberiotoxin also inhibited UI-induced vasodilation. The residual vasodilation after L-NAME was eliminated with co-administration of iberiotoxin.

conclusionsUI elicits dilation of the retinal arterioles mediated by NO release and BKCa channel activation.

Indexed as

AnimalsArteriolesDinoprostEndothelium-Dependent Relaxing FactorsFemaleIn Vitro TechniquesMaleMicroscopy, VideoNG-Nitroarginine Methyl EsterNitric OxideNitroprussidePotassium ChannelsRetinal VesselsSus scrofaVasodilationVasodilator AgentsDinoprostEndothelium-Dependent Relaxing Factorsisopropyl unoprostoneNG-Nitroarginine Methyl EsterNitric OxideNitroprussidePotassium ChannelsVasodilator Agents

Identifiers

PMID26120274
PMCPMC4463970
OpenAlexW658277096

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.