ArticleIndian journal of dermatology
Study of Oxidative Stress in Different Forms of Leprosy.
Article in Indian journal of dermatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Whole mitogenome sequencing uncovers a relation between mitochondrial heteroplasmy and leprosy severity.Human genomics · 2023Article
- Rv3539 (PPE63) of Mycobacterium Tuberculosis Promotes Survival of Mycobacterium Smegmatis in Human Macrophages Cell Line via Cell Wall Modulation of Bacteria and Altering Host's Immune Response.Current microbiology · 2023Article
- Using SXRF and LA-ICP-TOFMS to Explore Evidence of Treatment and Physiological Responses to Leprosy in Medieval Denmark.Biology · 2023Article
- Protective Efficacy of BCG Vaccine againstVaccines · 2022Review
- Increased oxidative stress in elderly leprosy patients is related to age but not to bacillary load.PLoS neglected tropical diseases · 2021Article
- Cardiovascular disease risk factors and markers of oxidative stress and DNA damage in leprosy patients in Southern Nigeria.PLoS neglected tropical diseases · 2020Article
- Altered composition and functional profile of high-density lipoprotein in leprosy patients.PLoS neglected tropical diseases · 2020Article
- Neutrophils in Leprosy.Frontiers in immunology · 2019Review
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeprosy is a chronic infectious disease caused by Mycobacterium leprae. India records the highest number of new leprosy cases in the world. Oxidative stress may play a significant role in leprosy.
aimThe aim of the study was to evaluate oxidative stress in various forms of leprosy and compared to healthy controls. MATERIALS AND
methodsSeventy newly diagnosed, untreated leprosy patients were selected as cases and sixty healthy controls. Oxidative stress was evaluated by measuring serum malondialdehyde (MDA) level and superoxide dismutase (SOD) activity. Student's unpaired t-test and Anova (Analysis of Variance) test were used for analysis of data. P < 0.05 was considered as significant.
resultsThere was a statistically significant increase in the mean values of serum MDA level, MDA/SOD and a decrease in serum SOD activity in cases when compared to controls and the values were significantly associated with increased duration, bacterial load and multibacillary type in leprosy.
conclusionOur study suggests that there was oxidative stress in leprosy. This warrants antioxidant supplementation to prevent tissue injury.
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Registered trials
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