ArticleProstaglandins, leukotrienes, and essential fatty acids2015
Distribution of omega-6 and omega-3 polyunsaturated fatty acids in the whole rat body and 25 compartments.
Article in Prostaglandins, leukotrienes, and essential fatty acids, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 46 citations in OpenAlex.
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- Arachidonic acid metabolism in health and disease.MedComm · 2023Review
- The Supplementation of Docosahexaenoic Acid-Concentrated Fish Oil Enhances Cognitive Function in Puppies.Animals : an open access journal from MDPI · 2023Article
- The Effects of a Low Linoleic Acid/α-Linolenic Acid Ratio on Lipid Metabolism and Endogenous Fatty Acid Distribution in Obese Mice.International journal of molecular sciences · 2023Article
- Docosahexaenoic Acid as Master Regulator of Cellular Antioxidant Defenses: A Systematic Review.Antioxidants (Basel, Switzerland) · 2023Review
- Demonstrating a link between diet, gut microbiota and brain:Frontiers in nutrition · 2023Article
- Lipid-based regulators of immunity.Bioengineering & translational medicine · 2022Review
- Lipid signature of neural tissues of marine and terrestrial mammals: consistency across species and habitats.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- Natural and Synthetic α-Tocopherol Modulate the Neuroinflammatory Response in the Spinal Cord of AdultCurrent developments in nutrition · 2021Article
- Hepatic endoplasmic reticulum calcium fluxes: effect of free fatty acids and KATP channel involvement.Bioscience reports · 2021Article
- Omega-3 Fatty Acids Prevent Post-Traumatic Stress Disorder-Induced Memory Impairment.Biomolecules · 2019Article
- Arachidonic acid: Physiological roles and potential health benefits - A review.Journal of advanced research · 2018Review
- Physical activity level among children recovering from severe acute malnutrition.Tropical medicine & international health : TM & IH · 2018Article
- Diabetes-induced abnormalities of mitochondrial function in rat brain cortex: the effect of n-3 fatty acid diet.Molecular and cellular biochemistry · 2017Article
- Interactive effects of dietary lipids and vitamin E level on performance, blood eicosanoids, and response to mitogen stimulation in broiler chickens of different ages.Poultry science · 2017Article
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- The Essentiality of Arachidonic Acid in Infant Development.Nutrients · 2016Review
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
The steady state compositions of omega-6 and omega-3 polyunsaturated fatty acids (PUFA) throughout the various viscera and tissues within the whole body of rats have not previously been described in a comprehensive manner. Dams consumed diets containing 10wt% fat (15% linoleate and 3% α-linolenate). Male offspring (n=9) at 7-week of age were euthanized and dissected into 25 compartments. Total lipid fatty acids for each compartment were quantified by GC/FID and summed for the rat whole body; total n-6 PUFA was 12wt% and total n-3 PUFA was 2.1% of total fatty acids. 18:2n-6 accounted for 84% of the total n-6 PUFA, 20:4n-6 was 12%, 18:3n-3 was 59% of the total n-3 PUFA, 20:5n-3 was 2.1%, and 22:6n-3 was 32%. The white adipose tissue contained the greatest amounts of 18:2n-6 (1.5g) and 18:3n-3 (0.2g). 20:4n-6 was highest in muscle (60mg) and liver (57mg), while 22:6n-3 was greatest in muscle (46mg), followed by liver (27mg) and carcass (20mg). In terms of fatty acid composition expressed as a percentage, 18:2n-6 was the highest in the heart (13wt%), while 18:3n-3 was about 1.3wt% for skin, white adipose tissue and fur. 20:4n-6 was highest (21-25wt%) in the circulation, kidney, and spleen, while 22:6n-3 was highest in the brain (12wt%), followed by the heart (7.9wt%), liver (5.9wt%), and spinal cord (5.1wt%). Selectivity was greatest when comparing 22:6n-3 in brain (12%) to white adipose (0.08%) (68-fold) and 22:5n-6 in testes (15.6%) compared to white adipose (0.02%), 780-fold.
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