SynthesisPain medicine (Malden, Mass.)2015
Chronic Pain in HIV-Infected Patients: Relationship to Depression, Substance Use, and Mental Health and Pain Treatment.
Synthesis in Pain medicine (Malden, Mass.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 3 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- A meta-analysis of the associations of elements of the fear-avoidance model of chronic pain with negative affect, depression, anxiety, pain-related disability and pain intensity.European journal of pain (London, England) · 2022Pooled it
- Pharmacologic and Non-Pharmacologic Interventions for HIV-Neuropathy Pain. A Systematic Review and a Meta-Analysis.Medicina (Kaunas, Lithuania) · 2019Pooled it
- Pooled it
- Trajectories of Pain Impact and Pain Self-Efficacy in People With HIV and Chronic Pain: Extending Findings From the Skills TO Manage Pain Randomized Clinical Trial.Journal of acquired immune deficiency syndromes (1999) · 2025Trial
- Addressing Pain and Heavy Drinking among Patients in HIV-Care: A Pilot Study of an Integrated Telehealth Intervention.AIDS and behavior · 2025Trial
- Health Care Service Utilization Among People with HIV, Chronic Pain, and Depression: Utilization and Cost Outcomes from the HIV-PASS Study.AIDS and behavior · 2025Trial
- Positive affect skills may improve pain management in people with HIV.Journal of health psychology · 2020Trial
- Daily factors driving daily substance use and chronic pain among older adults with HIV: An exploratory study using ecological momentary assessment.Alcohol (Fayetteville, N.Y.) · 2019Trial
- Pilot Randomized Trial of Collaborative Behavioral Treatment for Chronic Pain and Depression in Persons Living with HIV/AIDS.AIDS and behavior · 2016Trial
- HIV-related Stigma and Alcohol Involvement Among People with HIV Who Engage in Unhealthy Drinking.AIDS and behavior · 2026Article
- Cocaine Use, Unhealthy Alcohol Use, and Pain Interference Among People with HIV.AIDS and behavior · 2026Article
- Chronic pain in a modern virally suppressed HIV cohort is associated with disability and poorer mental health.Scientific reports · 2026Observational
- Factors Associated With Loss to Follow-Up Among People Living With HIV in a National Tertiary Care Hospital: Protocol and Baseline Analysis of a Prospective Cohort Study.JMIR research protocols · 2026Article
- Perceived disabling physical pain and suicidal ideation in aging people living with HIV cured of hepatitis C: A multi-center survey in France (ANRS CO13 HEPAVIH).HIV medicine · 2026Article
- Understanding risk and protective factors for pain and healthy aging: an intersectional and resilience-based perspective.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Pain and alcohol consumption among people living with HIV: examining the moderating roles of depression and social support.Alcohol (Fayetteville, N.Y.) · 2025Article
- Lessons Learned Identifying and Controlling Fraudulent Participation in Online Randomized Trials.Journal of medical Internet research · 2025Article
- Acceptability of a Smartphone-Based Music Intervention for Chronic Pain and Problematic Opioid Use Among People with HIV: A Mixed-Methods Pilot Study.AIDS research and human retroviruses · 2025Article
- Pain and unhealthy alcohol use among people living with HIV: A prospective cohort study.Alcohol, clinical & experimental research · 2024Article
- Integrated telehealth intervention to reduce chronic pain and unhealthy drinking among people living with HIV: protocol for a randomized controlled trial.Addiction science & clinical practice · 2024Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveAs the advent of highly active antiretroviral therapy, HIV has become a chronic disease for most individuals in developed countries. Chronic pain is a common occurrence for HIV-infected patients and has an impact on quality of life and antiretroviral adherence. The objective of this study was to examine relationships between chronic pain and depression, substance use, mental health treatment, and pain treatment in HIV-infected patients.
designCross-sectional study.
settingThree primary care sites where HIV+ patients receive treatment. SUBJECTS: Two hundred and thirty eight HIV-infected primary care patients.
methodsWe collected self-report and chart-review information on demographics, HIV clinical status, chronic pain, depression, substance use, mental health treatment, and pain treatment. We collected data between October 2012 and November 2013.
resultsOf the patients enrolled in this study, 107 reported no chronic pain, 24 reported mild chronic pain, and 107 reported moderate-severe chronic pain. Participants in the moderate-severe pain group were more likely to have high levels of depressive symptoms than those in the no chronic pain group. Similarly, there was a significant relationship between chronic pain status and interference with life activities due to pain. Participants with moderate-severe chronic pain were more likely to be taking an antidepressant medication than those with mild chronic pain, and more likely to be taking a prescription opioid than the other two groups. We did not find a significant relationship between problematic substance use and chronic pain status.
conclusionsDespite pharmacologic treatment, moderate-severe chronic pain and elevated depression symptoms are common among HIV-infected patients and frequently co-occur.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.