Evidence map›Paper›PMID 26119571›Full record

ReviewNature reviews. Microbiology2015

HIV-1 assembly, release and maturation.

Eric O Freed

Abstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 377 papers.

0numbers the graph read from it
0cells of the map it votes in
377citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

377 citing papers in PubMed.

  1. Article
  2. Article
  3. Manipulation of the cell cycle by HIV-1.Biochemical Society transactions · 2026
    Review
  4. Mechanisms of HIV-1 assembly, release and maturation.Nature reviews. Microbiology · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Mechanism of HIV-1 Capsid Rupture and Uncoating by Reverse Transcription.bioRxiv : the preprint server for biology · 2026
    Article
  12. HIV-1 Vif-dependent SUMOylation regulates viral RNA splicing.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  13. Review
  14. Article
  15. Chemical reviews · 2026
    Review
  16. Review
  17. Article
  18. The biased adenosine-rich content of the HIV-1 genome serves as a molecular signature that facilitates efficient packaging.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  19. Mechanistic insights into lenacapavir-induced off-pathway HIV-1 capsid assembly.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  20. Article

317 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Eric O FreedVirus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Bg. 535, Room 110, 1050 Boyles St., Frederick, Maryland 21702-1201, USA.

Funding

Inhibition of HIV-1 MaturationZIABC010778 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI FREED, ERIC · 2009 to 2025
$9.7M
HIV-1 Gag Assembly and MaturationZIABC011720 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI FREED, ERIC · 2016 to 2025
$7.2M
Retroviral Gag Trafficking, Env Incorporation, and Virus AssemblyZIABC010775 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI FREED, ERIC · 2009 to 2015
$4.6M
Retrovirus Budding and Endosomal SortingZIABC010776 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI FREED, ERIC · 2009 to 2015
$3.5M
Intramural NIH HHS ZIA BC010775Intramural NIH HHS ZIA BC010776Intramural NIH HHS ZIA BC010778
6 · The paper itself

Abstract

Major advances have occurred in recent years in our understanding of HIV-1 assembly, release and maturation, as work in this field has been propelled forwards by developments in imaging technology, structural biology, and cell and molecular biology. This increase in basic knowledge is being applied to the development of novel inhibitors designed to target various aspects of virus assembly and maturation. This Review highlights recent progress in elucidating the late stages of the HIV-1 replication cycle and the related interplay between virology, cell and molecular biology, and drug discovery.

Indexed as

Gene Expression Regulation, ViralHIV-1HumansViral ProteinsVirus AssemblyVirus ReleaseVirus ReplicationViral Proteins

Identifiers

PMID26119571
PMCPMC6936268

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.