Evidence map›Paper›PMID 26119471›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016

Functional Genetic Variation in Dopamine Signaling Moderates Prefrontal Cortical Activity During Risky Decision Making.

Milky Kohno, Erika L Nurmi, Christopher P Laughlin, Angelica M Morales, Emma H Gail, Gerhard S Hellemann, Edythe D London

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Evidence for pro-cognitive benefits of cannabinoids in people with bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Ventral striatal response during decision making involving risk and reward is associated with future binge drinking in adolescents.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
    Article
  14. Article
  15. Neural underpinnings of maladaptive decision-making in addictions.Pharmacology, biochemistry, and behavior · 2018
    Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Milky KohnoDepartment of Psychiatry and Biobehavioral Sciences and Semel Institute, University of California Los Angeles, Los Angeles, CA, USA.
Erika L NurmiDepartment of Psychiatry and Biobehavioral Sciences and Semel Institute, University of California Los Angeles, Los Angeles, CA, USA.
Christopher P LaughlinDepartment of Psychiatry and Biobehavioral Sciences and Semel Institute, University of California Los Angeles, Los Angeles, CA, USA.
Angelica M MoralesDepartment of Psychiatry and Biobehavioral Sciences and Semel Institute, University of California Los Angeles, Los Angeles, CA, USA.
Emma H GailDepartment of Psychiatry and Biobehavioral Sciences and Semel Institute, University of California Los Angeles, Los Angeles, CA, USA.
Gerhard S HellemannDepartment of Psychiatry and Biobehavioral Sciences and Semel Institute, University of California Los Angeles, Los Angeles, CA, USA.
Edythe D LondonDepartment of Psychiatry and Biobehavioral Sciences and Semel Institute, University of California Los Angeles, Los Angeles, CA, USA.
University of California, Los Angeles · US

Funding

UCLA Training Program in Translational Neuroscience of Drug Abuse (TNDA)T32DA024635 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY, Kate M Wassum · 2008 to 2026
$6.2M
NIDA NIH HHS T32 DA 024635NIDA NIH HHS T32 DA024635
6 · The paper itself

Abstract

Brain imaging has revealed links between prefrontal activity during risky decision-making and striatal dopamine receptors. Specifically, striatal dopamine D2-like receptor availability is correlated with risk-taking behavior and sensitivity of prefrontal activation to risk in the Balloon Analogue Risk Task (BART). The extent to which these associations, involving a single neurochemical measure, reflect more general effects of dopaminergic functioning on risky decision making, however, is unknown. Here, 65 healthy participants provided genotypes and performed the BART during functional magnetic resonance imaging. For each participant, dopamine function was assessed using a gene composite score combining known functional variation across five genes involved in dopaminergic signaling: DRD2, DRD3, DRD4, DAT1, and COMT. The gene composite score was negatively related to dorsolateral prefrontal cortical function during risky decision making, and nonlinearly related to earnings on the task. Iterative permutations of all possible allelic variations (7777 allelic combinations) was tested on brain function in an independently defined region of the prefrontal cortex and confirmed empirical validity of the composite score, which yielded stronger association than 95% of all other possible combinations. The gene composite score also accounted for a greater proportion of variability in neural and behavioral measures than the independent effects of each gene variant, indicating that the combined effects of functional dopamine pathway genes can provide a robust assessment, presumably reflecting the cumulative and potentially interactive effects on brain function. Our findings support the view that the links between dopaminergic signaling, prefrontal function, and decision making vary as a function of dopamine signaling capacity.

Indexed as

Genetic VariationRisk-TakingAdolescentAdultBrain MappingCatechol O-MethyltransferaseDecision MakingDopamineDopamine Plasma Membrane Transport ProteinsFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsPrefrontal CortexCatechol O-MethyltransferaseCOMT protein, humanDopamineDopamine Plasma Membrane Transport ProteinsDRD2 protein, humanDRD3 protein, humanDRD4 protein, humanReceptors, Dopamine D2Receptors, Dopamine D3Receptors, Dopamine D4SLC6A3 protein, human

Identifiers

PMID26119471
PMCPMC4707816
OpenAlexW761669883

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.