Evidence map›Paper›PMID 26119421›Full record

ArticleMagnetic resonance imaging2015

Spatial variations in magnetic resonance-based diffusion of articular cartilage in knee osteoarthritis.

Aditi Guha, Cory Wyatt, Dimitrios C Karampinos, Lorenzo Nardo, Thomas M Link, Sharmila Majumdar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Advances in cartilage imaging techniques.Nature reviews. Rheumatology · 2026
    Review
  2. Applications of Diffusion-Weighted MRI to the Musculoskeletal System.Journal of magnetic resonance imaging : JMRI · 2024
    Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aditi GuhaDepartment of Radiology and Biomedical Imaging, University of San Francisco, San Francisco, CA, USA. Electronic address: aditi.guha@ucsf.edu.
Cory WyattDepartment of Radiology and Biomedical Imaging, University of San Francisco, San Francisco, CA, USA.
Dimitrios C KarampinosDepartment of Diagnostic and Interventional Radiology, Technische Universität München, Munich, Germany.
Lorenzo NardoDepartment of Radiology and Biomedical Imaging, University of San Francisco, San Francisco, CA, USA.
Thomas M LinkDepartment of Radiology and Biomedical Imaging, University of San Francisco, San Francisco, CA, USA.
Sharmila MajumdarDepartment of Radiology and Biomedical Imaging, University of San Francisco, San Francisco, CA, USA.

Funding

Morphological and Functional Musko-Skeletal ImagingR01AG017762 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAJUMDAR, SHARMILA · 2000 to 2011
$9.1M
MRI TO STUDY CARTILAGE/BONE INTERACTIONSR01AR046905 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAJUMDAR, SHARMILA · 1999 to 2015
$6.3M
Translation of Quantitative Imaging in OsteoarthritisP50AR060752 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SOUZA, RICHARD BRIAN · 2011 to 2015
$6.2M
MRI evaluation of cartilage protein content with multi-component T1rho/T2 at 7TF32AR062964 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WYATT, CORY R. · 2012 to 2013
$106k
NIAMS NIH HHS 1F32AR062964NIAMS NIH HHS F32 AR062964NIAMS NIH HHS P50 AR060752NIAMS NIH HHS R01 AR046905NIAMS NIH HHS R01AR046905NIA NIH HHS R01 AG017762NIA NIH HHS R01AG017762
6 · The paper itself

Abstract

purposeTo evaluate a pulse sequence combining stimulated echo diffusion preparation with a 3D segmented spoiled gradient echo (SPGR) acquisition for diffusion tensor imaging (DTI) of knee cartilage in healthy and osteoarthritis (OA) populations for early diagnosis and characterization of OA.

methodsDiffusion-weighted images of 40 subjects (20 healthy, 20 OA) at baseline and 20 subjects (10 healthy, 10 OA) at one year were obtained. The subjects were classified according to Kellgren Lawrence (KL) and whole organ magnetic resonance imaging scoring (WORMS) method acquired at 3 T. Cartilage full thickness and laminar mean diffusivity (MD) and fractional anisotropy (FA) values were quantified. The reproducibility of MD and FA values was assessed in five healthy human subjects based on test-retest scans.

resultsIn general, the full thickness MD values were higher in subjects with knee OA compared to healthy controls in both the baseline and follow up cohort. Laminar analysis MD and FA results were significantly different (p<0.05) between the bone-articular and articular layer with the articular layer having higher MD and lower FA value compared to the bone layer. The global reproducibility error was 6.5% for MD and 11.6% for FA.

conclusionThe diffusion-weighted stimulated echo-based sequence may be used as a valuable tool for early diagnosis and characterization of knee OA at 3 T in the future.

Indexed as

Diffusion Magnetic Resonance ImagingCartilage, ArticularFemaleHumansImaging, Three-DimensionalKnee JointMaleMiddle AgedOsteoarthritis, KneeReproducibility of Results3TCartilageDiffusion tensor imaging (DTI)Laminar analysisOsteoarthritis (OA)Stimulated echo (STE) pulse sequence

Identifiers

PMID26119421
PMCPMC4593725

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.