ArticleCell2015
The Developmental Rules of Neural Superposition in Drosophila.
Article in Cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Retinal calcium waves coordinate uniform tissue patterning of theScience (New York, N.Y.) · 2025Article
- Sequential and independent probabilistic events regulate differential axon targeting during development in Drosophila melanogaster.Nature neuroscience · 2025Article
- Three systems of circuit formation: assembly, updating and tuning.Nature reviews. Neuroscience · 2025Review
- Topographic Axes of Wiring Space Converge to Genetic Topography in Shaping the Human Cortical Layout.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Structure and Topography of Facial Branchiomotor Neuron Dendrites in Larval Zebrafish (Danio rerio).The Journal of comparative neurology · 2024Article
- Inter-plane feedback coordinates cell morphogenesis and maintains 3D tissue organization in the Drosophila pupal retina.Development (Cambridge, England) · 2024Article
- Synaptic promiscuity in brain development.Current biology : CB · 2024Review
- Genetic regulation of central synapse formation and organization in Drosophila melanogaster.Genetics · 2022Review
- Mating-driven variability in olfactory local interneuron wiring.Science advances · 2022Article
- Analysis of growth cone extension in standardized coordinates highlights self-organization rules during wiring of the Drosophila visual system.PLoS genetics · 2021Article
- Article
- Neural specification, targeting, and circuit formation during visual system assembly.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Achieving functional neuronal dendrite structure through sequential stochastic growth and retraction.eLife · 2020Article
- Neuronal strategies for meeting the right partner during brain wiring.Current opinion in neurobiology · 2020Review
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- Color vision in insects: insights from Drosophila.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Review
- Visualization of insect metamorphosis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Control of Synaptic Specificity by Establishing a Relative Preference for Synaptic Partners.Neuron · 2019Article
- Analysis of the genetically tractable crustacean Parhyale hawaiensis reveals the organisation of a sensory system for low-resolution vision.BMC biology · 2019Article
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6 authors.
Funding
Abstract
Complicated neuronal circuits can be genetically encoded, but the underlying developmental algorithms remain largely unknown. Here, we describe a developmental algorithm for the specification of synaptic partner cells through axonal sorting in the Drosophila visual map. Our approach combines intravital imaging of growth cone dynamics in developing brains of intact pupae and data-driven computational modeling. These analyses suggest that three simple rules are sufficient to generate the seemingly complex neural superposition wiring of the fly visual map without an elaborate molecular matchmaking code. Our computational model explains robust and precise wiring in a crowded brain region despite extensive growth cone overlaps and provides a framework for matching molecular mechanisms with the rules they execute. Finally, ordered geometric axon terminal arrangements that are not required for neural superposition are a side product of the developmental algorithm, thus elucidating neural circuit connectivity that remained unexplained based on adult structure and function alone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.