Evidence map›Paper›PMID 26119236›Full record

ArticleCell stem cell2015

Generation of Cynomolgus Monkey Chimeric Fetuses using Embryonic Stem Cells.

Yongchang Chen, Yuyu Niu, Yanjiao Li, Zongyong Ai, Yu Kang, Hong Shi, Zheng Xiang, Zhaohui Yang, Tao Tan, Wei Si and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Cell stem cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed.

  1. Article
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  5. Non-human primate: the new frontier model of female reproductive engineering.Frontiers in bioengineering and biotechnology · 2025
    Review
  6. Article
  7. Article
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  9. Article
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  11. Article
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  16. Gene editing monkeys: Retrospect and outlook.Frontiers in cell and developmental biology · 2022
    Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Yongchang ChenYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China; National Engineering Research Center of Biomedicine and Animal Science and Kunming Biomed International, Kunming, Yunnan 650500, China.
Yuyu NiuYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China; National Engineering Research Center of Biomedicine and Animal Science and Kunming Biomed International, Kunming, Yunnan 650500, China.
Yanjiao LiYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China; National Engineering Research Center of Biomedicine and Animal Science and Kunming Biomed International, Kunming, Yunnan 650500, China.
Zongyong AiYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China; National Engineering Research Center of Biomedicine and Animal Science and Kunming Biomed International, Kunming, Yunnan 650500, China.
Yu KangYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China; National Engineering Research Center of Biomedicine and Animal Science and Kunming Biomed International, Kunming, Yunnan 650500, China.
Hong ShiYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China; National Engineering Research Center of Biomedicine and Animal Science and Kunming Biomed International, Kunming, Yunnan 650500, China.
Zheng XiangYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China; National Engineering Research Center of Biomedicine and Animal Science and Kunming Biomed International, Kunming, Yunnan 650500, China.
Zhaohui YangYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China; National Engineering Research Center of Biomedicine and Animal Science and Kunming Biomed International, Kunming, Yunnan 650500, China.
Tao TanYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China; National Engineering Research Center of Biomedicine and Animal Science and Kunming Biomed International, Kunming, Yunnan 650500, China.
Wei SiYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China; National Engineering Research Center of Biomedicine and Animal Science and Kunming Biomed International, Kunming, Yunnan 650500, China.
Wei LiState Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Xueshan XiaYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China.
Qi ZhouState Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: qzhou@ioz.ac.cn.
Weizhi JiYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China; National Engineering Research Center of Biomedicine and Animal Science and Kunming Biomed International, Kunming, Yunnan 650500, China. Electronic address: wji@kbimed.com.
Tianqing LiYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China; National Engineering Research Center of Biomedicine and Animal Science and Kunming Biomed International, Kunming, Yunnan 650500, China. Electronic address: litq@kbimed.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Because of their similarity to humans, non-human primates are important models for studying human disease and developing therapeutic strategies. Establishment of chimeric animals using embryonic stem cells (ESCs) could help with these investigations, but has not so far been achieved. Here, we show that cynomolgus monkey ESCs (cESCs) grown in adjusted culture conditions are able to incorporate into host embryos and develop into chimeras with contribution in all three germ layers and in germ cell progenitors. Under the optimized culture conditions, which are based on an approach developed previously for naive human ESCs, the cESCs displayed altered growth properties, gene expression profiles, and self-renewal signaling pathways, suggestive of an altered naive-like cell state. Thus our findings show that it is feasible to generate chimeric monkeys using ESCs and open up new avenues for the use of non-human primate models to study both pluripotency and human disease.

Indexed as

AnimalsBlastocystCell DifferentiationCells, CulturedEmbryonic Stem CellsFemaleHumansMacaca fascicularisMaleModels, AnimalMorulaPregnancyTestisTranscriptomeTransplantation Chimera

Identifiers

PMID26119236

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.