Evidence map›Paper›PMID 26119177›Full record

ReviewHearing research2015

Decreased temporal precision of neuronal signaling as a candidate mechanism of auditory processing disorder.

Conny Kopp-Scheinpflug, Bruce L Tempel

Open access · hybridAbstract readReview
In one paragraph

Review in Hearing research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Loss of β4-spectrin impairs NaScientific reports · 2022
    Article
  7. Review
  8. Review
  9. Article
  10. Axonal Computations.Frontiers in cellular neuroscience · 2019
    Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Changes in Properties of Auditory Nerve Synapses following Conductive Hearing Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Conny Kopp-ScheinpflugDivision of Neurobiology, Department Biology II, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany. Electronic address: cks@bio.lmu.de.
Bruce L TempelVM Bloedel Hearing Research Center and Departments of Otolaryngology-HNS and Pharmacology, University of Washington, Seattle, WA, USA; Department of Otolaryngology-HNS, University of Washington, Seattle, WA, USA; Department of Pharmacology, University of Washington, Seattle, WA, USA.
Ludwig-Maximilians-Universität München · DEUniversity of Washington · US

Funding

UNIVERSITY OF WASHINGTON RESEARCH CORE CENTERP30DC004661 · NIDCD · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W, STONE, JENNIFER S. · 2000 to 2014
$11.1M
GENETIC MODEL FOR CONGENITAL DEAFNESSR01DC002739 · NIDCD · UNIVERSITY OF WASHINGTON · PI TEMPEL, BRUCE L · 1995 to 2013
$4.1M
LincRNAs Regulate Atp2b2, Potentially Determining PMCA2 Quantity in StereociliaR21DC014864 · NIDCD · UNIVERSITY OF WASHINGTON · PI TEMPEL, BRUCE L · 2015 to 2016
$407k
NIDCD NIH HHS P30 DC004661NIDCD NIH HHS R01 DC002739NIDCD NIH HHS R21 DC014864
6 · The paper itself

Abstract

The sense of hearing is the fastest of our senses and provides the first all-or-none action potential in the auditory nerve in less than four milliseconds. Short stimulus evoked latencies and their minimal variability are hallmarks of auditory processing from spiral ganglia to cortex. Here, we review how even small changes in first spike latencies (FSL) and their variability (jitter) impact auditory temporal processing. We discuss a number of mouse models with degraded FSL/jitter whose mutations occur exclusively in the central auditory system and therefore might serve as candidates to investigate the cellular mechanisms underlying auditory processing disorders (APD).

Indexed as

Auditory PerceptionHearingSynaptic TransmissionAcoustic StimulationAnimalsAuditory PathwaysAuditory Perceptual DisordersDisease Models, AnimalEvoked Potentials, Auditory, Brain StemGenetic Predisposition to DiseaseHumansMiceMutationNerve Tissue ProteinsPhenotypeReaction TimeNerve Tissue ProteinsAuditory brainstem responsesAuditory processing disorderFirst spike latencyJitterKv1.1QuiveringβIV-spectrin

Identifiers

PMID26119177
PMCPMC4689642
OpenAlexW748218359

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.