Evidence map›Paper›PMID 26119168›Full record

ArticleJournal of veterinary science2015

Elevated level of renal xanthine oxidase mRNA transcription after nephropathogenic infectious bronchitis virus infection in growing layers.

Huayuan Lin, Qiqi Huang, Xiaoquan Guo, Ping Liu, Weilian Liu, Yuelong Zou, Shuliang Zhu, Guangfu Deng, Jun Kuang, Caiying Zhang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Nephropathogenic Infectious Bronchitis Virus Mediates Kidney Injury in ChickensFrontiers in cellular and infection microbiology · 2022
    Article
  2. A Review of Emerging Goose Astrovirus Causing Gout.BioMed research international · 2022
    Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Huayuan LinClinical Veterinary Laboratory, College of Animal Science and Technology, Jiangxi Agricultural University, Jiangxi 330029, China.
Qiqi HuangClinical Veterinary Laboratory, College of Animal Science and Technology, Jiangxi Agricultural University, Jiangxi 330029, China.
Xiaoquan GuoClinical Veterinary Laboratory, College of Animal Science and Technology, Jiangxi Agricultural University, Jiangxi 330029, China.
Ping LiuClinical Veterinary Laboratory, College of Animal Science and Technology, Jiangxi Agricultural University, Jiangxi 330029, China.
Weilian LiuClinical Veterinary Laboratory, College of Animal Science and Technology, Jiangxi Agricultural University, Jiangxi 330029, China.
Yuelong ZouClinical Veterinary Laboratory, College of Animal Science and Technology, Jiangxi Agricultural University, Jiangxi 330029, China.
Shuliang ZhuClinical Veterinary Laboratory, College of Animal Science and Technology, Jiangxi Agricultural University, Jiangxi 330029, China.
Guangfu DengClinical Veterinary Laboratory, College of Animal Science and Technology, Jiangxi Agricultural University, Jiangxi 330029, China.
Jun KuangClinical Veterinary Laboratory, College of Animal Science and Technology, Jiangxi Agricultural University, Jiangxi 330029, China.
Caiying ZhangClinical Veterinary Laboratory, College of Animal Science and Technology, Jiangxi Agricultural University, Jiangxi 330029, China.
Huabin CaoClinical Veterinary Laboratory, College of Animal Science and Technology, Jiangxi Agricultural University, Jiangxi 330029, China.
Guoliang HuClinical Veterinary Laboratory, College of Animal Science and Technology, Jiangxi Agricultural University, Jiangxi 330029, China.
Jiangxi Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To assess relationships between xanthine oxidase (XOD) and nephropathogenic infectious bronchitis virus (NIBV) infection, 240 growing layers (35 days old) were randomly divided into two groups (infected and control) of 120 chickens each. Each chicken in the control and infected group was intranasally inoculated with 0.2 mL sterile physiological saline and virus, respectively, after which serum antioxidant parameters and renal XOD mRNA expression in growing layers were evaluated at 8, 15 and 22 days post-inoculation (dpi). The results showed that serum glutathione peroxidase and superoxide dismutase activities in the infected group were significantly lower than in the control group at 8 and 15 dpi (p < 0.01), while serum malondialdehyde concentrations were significantly higher (p < 0.01). The serum uric acid was significantly higher than that of the control group at 15 dpi (p < 0.01). In addition, the kidney mRNA transcript level and serum activity of XOD in the infected group was significantly higher than that of the control group at 8, 15 and 22 dpi (p < 0.05). The results indicated that NIBV infection could cause the increases of renal XOD gene transcription and serum XOD activity, leading to hyperuricemia and reduction of antioxidants in the body.

Indexed as

ChickensAnimalsAntioxidantsCoronavirus InfectionsFemaleInfectious bronchitis virusKidneyPoultry DiseasesReal-Time Polymerase Chain ReactionRNA, MessengerTranscription, GeneticUric AcidXanthine OxidaseAntioxidantsRNA, MessengerUric AcidXanthine Oxidaseantioxidantgrowing layershyperuricemianephropathogenic infectious bronchitis virusxanthine oxidase

Identifiers

PMID26119168
PMCPMC4701734
OpenAlexW2277690289

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.