Evidence map›Paper›PMID 26119026›Full record

ArticleNeuron2015

Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation.

Sébastien Talbot, Raja-Elie E Abdulnour, Patrick R Burkett, Seungkyu Lee, Shane J F Cronin, Maud A Pascal, Cedric Laedermann, Simmie L Foster, Johnathan V Tran, Nicole Lai and 13 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 274 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
274citing papers in PubMed, 3 pooled it
15.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

274 citing papers in PubMed, 3 syntheses or guidelines pooled it, 426 citations in OpenAlex.

  1. Pooled it
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  12. VipCell reports · 2026
    Article
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  20. Sulfolipid-1 fromJournal of neurophysiology · 2026
    Article

214 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 6 institutions in 3 countries.

Sébastien TalbotFM Kirby Neurobiology Center, Children's Hospital Boston, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Raja-Elie E AbdulnourPulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Patrick R BurkettPulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Seungkyu LeeFM Kirby Neurobiology Center, Children's Hospital Boston, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Shane J F CroninFM Kirby Neurobiology Center, Children's Hospital Boston, Boston, MA 02115, USA; IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna 1030, Austria.
Maud A PascalFM Kirby Neurobiology Center, Children's Hospital Boston, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; Département de biologie, École Normale Supérieure de Cachan, Cachan 94230, France.
Cedric LaedermannFM Kirby Neurobiology Center, Children's Hospital Boston, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Simmie L FosterFM Kirby Neurobiology Center, Children's Hospital Boston, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Johnathan V TranFM Kirby Neurobiology Center, Children's Hospital Boston, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Nicole LaiFM Kirby Neurobiology Center, Children's Hospital Boston, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Isaac M ChiuFM Kirby Neurobiology Center, Children's Hospital Boston, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Nader GhasemlouFM Kirby Neurobiology Center, Children's Hospital Boston, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Matthew DiBiaseFM Kirby Neurobiology Center, Children's Hospital Boston, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
David RobersonFM Kirby Neurobiology Center, Children's Hospital Boston, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Christian Von HehnFM Kirby Neurobiology Center, Children's Hospital Boston, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Busranour AgacFM Kirby Neurobiology Center, Children's Hospital Boston, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Oliver HaworthPulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Hiroyuki SekiPulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Josef M PenningerIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna 1030, Austria.
Vijay K KuchrooCenter for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Bruce P BeanDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Bruce D LevyPulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: blevy@partners.org.
Clifford J WoolfFM Kirby Neurobiology Center, Children's Hospital Boston, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: clifford.woolf@childrens.harvard.edu.
Boston Children's Hospital · USHarvard University · USBrigham and Women's Hospital · USAustrian Academy of Sciences · ATÉcole Normale Supérieure Paris-Saclay · FRInstitute of Molecular Biotechnology · AT

Funding

SYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESISP30HD018655 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI POMEROY, SCOTT LOREN · 1985 to 2015
$26.2M
RESPIRATORY RESEARCHT32HL007633 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI George R Washko · 1985 to 2026
$14.9M
Resolution Mechanisms in Acute Inflammation: Resolution PharmacologyP01GM095467 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SERHAN, CHARLES NICHOLAS · 2011 to 2020
$14.8M
TRP Channel Mediated Pain CircuitryP01NS072040 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI WOOLF, CLIFFORD J · 2011 to 2015
$6.7M
Neural Plasticity and Inflammatory PainR37NS039518 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI WOOLF, CLIFFORD J · 2011 to 2017
$4.7M
Specialized Pro-Resolving Mediators in AsthmaR01HL122531 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LEVY, BRUCE D · 2014 to 2024
$4.7M
Lipid Mediators in the Resolution of Asthma ExacerbationsR01AI068084 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI LEVY, BRUCE D · 2005 to 2008
$2.0M
Lipid Mediators In The Resolution of Asthma ExacerbationsR56AI068084 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI LEVY, BRUCE D · 2010 to 2010
$429k
The role of nociceptor neurons in bacterial host defense and inflammationK22AI114810 · NIAID · HARVARD MEDICAL SCHOOL · PI CHIU, ISAAC MING-CHENG · 2015 to 2016
$270k
The Role of Direct Pathogen Detection by Sensory Neurons in Combating Bacterial IF32NS076297 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI CHIU, ISAAC MING-CHENG · 2011 to 2012
$105k
NHLBI NIH HHS 5T32HL007633NHLBI NIH HHS R01 HL122531NHLBI NIH HHS R01-HL122531NHLBI NIH HHS T32 HL007633NIAID NIH HHS AI068084NIAID NIH HHS K22 AI114810NIAID NIH HHS R01 AI068084NIAID NIH HHS R56 AI068084NICHD NIH HHS P30 HD018655NICHD NIH HHS P30-HD18655NIGMS NIH HHS P01 GM095467NIGMS NIH HHS P01-GM095467NINDS NIH HHS F32 NS076297NINDS NIH HHS F32 NS076297-01NINDS NIH HHS P01 NS072040NINDS NIH HHS P01NS072040NINDS NIH HHS R37 NS039518NINDS NIH HHS R37NS039518
6 · The paper itself

Abstract

Lung nociceptors initiate cough and bronchoconstriction. To elucidate if these fibers also contribute to allergic airway inflammation, we stimulated lung nociceptors with capsaicin and observed increased neuropeptide release and immune cell infiltration. In contrast, ablating Nav1.8(+) sensory neurons or silencing them with QX-314, a charged sodium channel inhibitor that enters via large-pore ion channels to specifically block nociceptors, substantially reduced ovalbumin- or house-dust-mite-induced airway inflammation and bronchial hyperresponsiveness. We also discovered that IL-5, a cytokine produced by activated immune cells, acts directly on nociceptors to induce the release of vasoactive intestinal peptide (VIP). VIP then stimulates CD4(+) and resident innate lymphoid type 2 cells, creating an inflammatory signaling loop that promotes allergic inflammation. Our results indicate that nociceptors amplify pathological adaptive immune responses and that silencing these neurons with QX-314 interrupts this neuro-immune interplay, revealing a potential new therapeutic strategy for asthma.

Indexed as

Airway RemodelingAnesthetics, LocalAnimalsAnimals, NewbornCapsaicinCytokinesDisease Models, AnimalFreund's AdjuvantGreen Fluorescent ProteinsInterleukin-5LidocaineMiceNociceptorsOvalbuminRespiratory HypersensitivityTime FactorsAnesthetics, LocalCapsaicinCytokinesFreund's AdjuvantGreen Fluorescent ProteinsInterleukin-5LidocaineOvalbuminQX-314Vasoactive Intestinal Peptide

Identifiers

PMID26119026
PMCPMC4506220
OpenAlexW1513929611

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.