ArticleNeuroscience letters2015
Sex-specific alterations in hippocampal cannabinoid 1 receptor expression following adolescent delta-9-tetrahydrocannabinol treatment in the rat.
Article in Neuroscience letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Relationship between fMRI response during a nonverbal memory task and marijuana use in college students.Drug and alcohol dependence · 2018Trial
- Envisioning Cannabinoid CB1 Receptor Biased Signaling as a Therapeutic Target for Schizophrenia.The American journal of psychiatry · 2026Review
- Altered Network Function in Hippocampus After Sub-Chronic Activation of Cannabinoid Receptors in Early Adolescence.International journal of molecular sciences · 2025Article
- Altered network function in hippocampus after sub-chronic activation of Cannabis receptors in peri-adolescence.bioRxiv : the preprint server for biology · 2025Article
- The effects of moderate alcohol and THC co-use during male and female rat adolescence on AKT-GSK3ß signaling in adulthood.Behavioural brain research · 2025Article
- Experience with dronabinol consumption facilitated a stimulant effect of alcohol and affected alcohol-related changes in frontal cortical endocannabinoid levels in male rats.Behavioural brain research · 2023Article
- Chronic Δ9-tetrahydrocannabinol treatment has dose-dependent effects on open field exploratory behavior and [Life sciences · 2023Article
- Cannabis in Adolescence: Lasting Cognitive Alterations and Underlying Mechanisms.Cannabis and cannabinoid research · 2023Review
- Cell-autonomous and differential endocannabinoid signaling impacts the development of presynaptic retinal ganglion cell axon connectivityFrontiers in synaptic neuroscience · 2023Article
- Persistent sexually dimorphic effects of adolescent THC exposure on hippocampal synaptic plasticity and episodic memory in rodents.Neurobiology of disease · 2022Article
- Persistent Exposure to ΔThe Journal of pharmacology and experimental therapeutics · 2021Article
- Pharmacokinetic, behavioral, and brain activity effects of ΔNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Sex, species and age: Effects of rodent demographics on the pharmacology of ∆Progress in neuro-psychopharmacology & biological psychiatry · 2021Article
- Resting state functional connectivity in the default mode network: Relationships between cannabis use, gender, and cognition in adolescents and young adults.NeuroImage. Clinical · 2021Article
- Intravenous self-administration of delta-9-THC in adolescent rats produces long-lasting alterations in behavior and receptor protein expression.Psychopharmacology · 2021Article
- Vaporized Cannabis Extracts Have Reinforcing Properties and Support Conditioned Drug-Seeking Behavior in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Sex, THC, and hormones: Effects on density and sensitivity of CBDrug and alcohol dependence · 2019Article
- Mechanisms Underlying Sex Differences in Cannabis Use.Current addiction reports · 2017Article
- Marijuana Use Is Associated with Behavioral Approach and Depressive Symptoms in Adolescents and Emerging Adults.PloS one · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Marijuana use by adolescents has been on the rise since the early 1990s. With recent legalization and decriminalization acts passed, cannabinoid exposure in adolescents will undoubtedly increase. Human studies are limited in their ability to examine underlying changes in brain biochemistry making rodent models valuable. Studies in adult and adolescent animals show region and sex specific downregulation of the cannabinoid 1 (CB1) receptor following chronic cannabinoid treatment. However, although sex-dependent changes in behavior have been observed during the drug abstinence period following adolescent cannabinoid exposure, little is known about CB1 receptor expression during this critical time. In order to characterize CB1 receptor expression following chronic adolescent Δ-9-tetrahydrocannabinol (THC) exposure, we used [(3)H] CP55,940 binding to assess CB1 receptor expression in the dentate gyrus and areas CA1, CA2, and CA3 of the hippocampus in both male and female adolescent rats at both 24h and 2 weeks post chronic THC treatment. Consistent with other reported findings, we found downregulation of the CB1 receptor in the hippocampal formation at 24h post treatment. While this downregulation persisted in both sexes following two weeks of abstinence in the CA2 region, in females, this downregulation also persisted in areas CA1 and CA3. Expression in the dentate gyrus returned to the normal range by two weeks. These data suggest that selective regions of the hippocampus show persistent reductions in CB1 receptor expression and that these reductions are more widespread in female compared to male adolescents.
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