ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging
Whole Brain Volume Measured from 1.5T versus 3T MRI in Healthy Subjects and Patients with Multiple Sclerosis.
Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Predictors of multiple sclerosis progression: A systematic review of conventional magnetic resonance imaging studies.PloS one · 2024Pooled it
- The efficacy of multisite MRI scanners for total brain volume measurements: a cross-sectional study in Saudi Arabia.Frontiers in radiology · 2026Article
- Gut microbiota and metabolites are linked to disease progression in multiple sclerosis.Cell reports. Medicine · 2025Article
- Brain age in multiple sclerosis: a study with deep learning and traditional machine learning.Brain communications · 2025Article
- A systematic literature review of the association between global brain atrophy and the Expanded Disability Status Scale score in people with multiple sclerosis.Therapeutic advances in neurological disorders · 2025Review
- External evaluation of a deep learning-based approach for automated brain volumetry in patients with huntington's disease.Scientific reports · 2024Article
- Article
- Reliability of brain atrophy measurements in multiple sclerosis using MRI: an assessment of six freely available software packages for cross-sectional analyses.Neuroradiology · 2023Article
- Effect of magnet strength on fetal brain biometry - a single-center retrospective MRI-based cohort study.Neuroradiology · 2023Article
- Brain Atrophy as an Outcome of Disease-Modifying Therapy for Remitting-Relapsing Multiple Sclerosis.Multiple sclerosis international · 2023Review
- Machine learning in neuro-oncology: toward novel development fields.Journal of neuro-oncology · 2022Review
- Predictive MRI Biomarkers in MS-A Critical Review.Medicina (Kaunas, Lithuania) · 2022Review
- Alzheimer's Disease Diagnosis With Brain Structural MRI Using Multiview-Slice Attention and 3D Convolution Neural Network.Frontiers in aging neuroscience · 2022Article
- Gut Microbiome in Progressive Multiple Sclerosis.Annals of neurology · 2021Article
- DeepGRAI (Deep Gray Rating via Artificial Intelligence): Fast, feasible, and clinically relevant thalamic atrophy measurement on clinical quality T2-FLAIR MRI in multiple sclerosis.NeuroImage. Clinical · 2021Article
- Assessment of brain volumes obtained from MP-RAGE and MP2RAGE images, quantified using different segmentation methods.Magma (New York, N.Y.) · 2020Article
- Lasting consequences of concussion on the aging brain: Findings from the Baltimore Longitudinal Study of Aging.NeuroImage · 2020Article
- Regional microglial activation in the substantia nigra is linked with fatigue in MS.Neurology(R) neuroimmunology & neuroinflammation · 2020Article
- Brain MRI Predicts Worsening Multiple Sclerosis Disability over 5 Years in the SUMMIT Study.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2020Article
- Standardized Brain MRI Acquisition Protocols Improve Statistical Power in Multicenter Quantitative Morphometry Studies.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhole brain atrophy is a putative outcome measure in monitoring relapsing-remitting multiple sclerosis (RRMS). With the ongoing MRI transformation from 1.5T to 3T, there is an unmet need to calibrate this change. We evaluated brain parenchymal volumes (BPVs) from 1.5T versus 3T in MS and normal controls (NC).
methodsWe studied MS [n = 26, age (mean, range) 43 (21-55), 22 (85%) RRMS, Expanded Disability Status Scale (EDSS) 1.98 (0-6.5), timed 25 foot walk (T25FW) 5.95 (3.2-33.0 seconds)] and NC [n = 9, age 45 (31-53)]. Subjects underwent 1.5T (Phillips) and 3T (GE) 3-dimensional T1-weighted scans to derive normalized BPV from an automated SIENAX pipeline. Neuropsychological testing was according to consensus panel recommendations.
resultsBPV-1.5T was higher than BPV-3T [mean (95% CI) + 45.7 mL (+35.3, +56.1), P < .00001], most likely due to improved tissue-CSF contrast at 3T. BPV-3T showed a larger volume decrease and larger effect size in detecting brain atrophy in MS versus NC [-74.5 mL (-126.5, -22.5), P = .006, d = .92] when compared to BPV-1.5T [-51.3.1 mL (-99.8, -2.8), P = .04, d = .67]. Correlations between BPV-1.5T and EDSS (r = -.43, P = .027) and BPV-3T and EDSS (r = -.49, P = .011) and between BPV-1.5T and T25FW (r = -.46, P = .018) and BPV-3T and T25FW (r = -.56, P = .003) slightly favored 3T. BPV-cognition correlations were significant (P < .05) for 6 of 11 subscales to a similar degree at 1.5T (r range = .44-.58) and 3T (r range = .43-.53).
conclusionsField strength may impact whole brain volume measurements in patients with MS though the differences are not too divergent between 1.5T and 3T.
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