ArticleSleep2015
Obstructive Sleep Apnea in Patients with Congenital Long QT Syndrome: Implications for Increased Risk of Sudden Cardiac Death.
Article in Sleep, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Obstructive sleep apnea and the risk of sudden cardiac death: a systematic review and meta-analysis.BMC cardiovascular disorders · 2025Pooled it
- Sudden death in individuals with obstructive sleep apnoea: a systematic review and meta-analysis.BMJ open respiratory research · 2021Pooled it
- Home Oxygen Therapy for Children. An Official American Thoracic Society Clinical Practice Guideline.American journal of respiratory and critical care medicine · 2019Guideline
- Trial
- Sleep, Neural Circulatory Control, and Cardiovascular Disease: A Mechanistic Review.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Impact of Obstructive Sleep Apnea-Hypopnea Syndrome Severity on Heart Rate Variability and QTc Interval in Hypertensive Patients.Medicina (Kaunas, Lithuania) · 2025Article
- Sex differences in cardiac transcriptomic response to neonatal sleep apnea.Physiological reports · 2024Article
- Cardiovascular Complications of Obstructive Sleep Apnea in the Intensive Care Unit and Beyond.Medicina (Kaunas, Lithuania) · 2022Review
- Confirmation of Cause of Death Via Comprehensive Autopsy and Whole Exome Molecular Sequencing in People With Epilepsy and Sudden Unexpected Death.Journal of the American Heart Association · 2021Article
- Sleep-Disordered Breathing and Cardiovascular Disease in Children and Adolescents: A Scientific Statement From the American Heart Association.Journal of the American Heart Association · 2021Article
- Effect of obstructive sleep apnea on right ventricular ejection fraction in patients with hypertrophic obstructive cardiomyopathy.Clinical cardiology · 2020Observational
- Daytime QT by Routine 12-Lead ECG Is Prolonged in Patients with Severe Obstructive Sleep Apnea.Sleep disorders · 2020Article
- Sleep Apnea and Sudden Cardiac Death.Circulation reports · 2019Article
- Ventricular Arrhythmias in Patients with Obstructive Sleep Apnea.Current cardiology reviews · 2019Review
- Review
- The role of declining adaptive homeostasis in ageing.The Journal of physiology · 2017Review
- Article
- Serum high-density lipoprotein correlates with serum apolipoprotein M and A5 in obstructive sleep apnea hypopnea syndrome.Sleep & breathing = Schlaf & Atmung · 2017Article
- Influence of functional polymorphism in MIF promoter on sudden cardiac death in Chinese populations.Forensic sciences research · 2017Article
- Autonomic nervous system and cardiac channelopathies in sleep apnea-one more piece of a complex puzzle?Sleep & breathing = Schlaf & Atmung · 2016Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundCongenital long QT syndrome (LQTS) is a familial arrhythmogenic cardiac channelopathy characterized by prolonged ventricular repolarization and increased risk of torsades de pointes-mediated syncope, seizures, and sudden cardiac death (SCD). QT prolongation corrected for heart rate (QTc) is an important diagnostic and prognostic feature in LQTS. Obstructive sleep apnea (OSA) has been increasingly implicated in the pathogenesis of cardiovascular disease, including arrhythmias and SCD. We tested the hypothesis that the presence of concomitant OSA in patients with LQTS is associated with increased QT intervals, both during sleep and while awake. METHODS AND
resultsPolysomnography with simultaneous overnight 12-lead electrocardiography (ECG) was recorded in 54 patients with congenital LQTS and 67 control subjects. OSA was diagnosed as apnea-hypopnea index (AHI) ≥ 5 events/h for adults and AHI > 1 event/h for children. RR and QT intervals were measured from the 12-lead surface ECG. QTc was determined by the Bazett formula. Respiratory disturbance index, AHI, and arousal index were significantly increased in patients with LQTS and with OSA compared to those without OSA and control subjects. QTc during different sleep stages and while awake was also significantly increased in patients with LQTS and OSA compared to those without OSA. Severity of OSA in patients with LQTS was directly associated with the degree of QTc.
conclusionsThe presence and severity of obstructive sleep apnea (OSA) in patients with congenital long QT syndrome (LQTS) is associated with increased QT prolongation corrected for heart rate, which is an important biomarker of sudden cardiac death (SCD). Treatment of OSA in LQTS patients may reduce QT prolongation, thus reducing the risk of LQT-triggered SCD.
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