Observational studyClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2016
Nitrous oxide-induced slow and delta oscillations.
Observational study in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- The cellular mechanisms associated with the anesthetic and neuroprotective properties of xenon: a systematic review of the preclinical literature.Frontiers in neuroscience · 2023Pooled it
- Oral Dexmedetomidine Promotes Non-rapid Eye Movement Stage 2 Sleep in Humans.Anesthesiology · 2020Trial
- Sex-specific electrophysiological and behavioral responses to nitrous oxide in a murine model of neuropathic pain.Biology of sex differences · 2026Article
- Ketamine can produce oscillatory dynamics by engaging mechanisms dependent on the kinetics of NMDA receptors.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Ketamine can produce oscillatory dynamics by engaging mechanisms dependent on the kinetics of NMDA receptors.bioRxiv : the preprint server for biology · 2024Article
- Support-vector classification of low-dose nitrous oxide administration with multi-channel EEG power spectra.Journal of clinical monitoring and computing · 2024Article
- Psychedelic concentrations of nitrous oxide reduce functional differentiation in frontoparietal and somatomotor cortical networks.Communications biology · 2023Article
- Quantitative relationship between anteriorization of alpha oscillations and level of general anesthesia.Journal of clinical monitoring and computing · 2023Article
- Thalamic T-Type Calcium Channels as Targets for Hypnotics and General Anesthetics.International journal of molecular sciences · 2022Review
- Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation.eLife · 2021Article
- Molecular Diversity of Anesthetic Actions Is Evident in Electroencephalogram Effects in Humans and Animals.International journal of molecular sciences · 2021Review
- A Pharmacokinetic and Pharmacodynamic Study of Oral Dexmedetomidine.Anesthesiology · 2020Article
- Improved tracking of sevoflurane anesthetic states with drug-specific machine learning models.Journal of neural engineering · 2020Article
- Analysis of brain connectivity during nitrous oxide sedation using graph theory.Scientific reports · 2020Article
- Electroencephalography: Clinical Applications During the Perioperative Period.Frontiers in medicine · 2020Review
- Drug-Specific Models Improve the Performance of an EEG-based Automated Brain-State Prediction System.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2019Article
- Association of electroencephalogram trajectories during emergence from anaesthesia with delirium in the postanaesthesia care unit: an early sign of postoperative complications.British journal of anaesthesia · 2019Observational
- Delta oscillations phase limit neural activity during sevoflurane anesthesia.Communications biology · 2019Article
- Astrocytic modulation of cortical oscillations.Scientific reports · 2018Article
- Time rescaling reproduces EEG behavior during transition from propofol anesthesia-induced unconsciousness to consciousness.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesSwitching from maintenance of general anesthesia with an ether anesthetic to maintenance with high-dose (concentration >50% and total gas flow rate >4 liters per minute) nitrous oxide is a common practice used to facilitate emergence from general anesthesia. The transition from the ether anesthetic to nitrous oxide is associated with a switch in the putative mechanisms and sites of anesthetic action. We investigated whether there is an electroencephalogram (EEG) marker of this transition.
methodsWe retrospectively studied the ether anesthetic to nitrous oxide transition in 19 patients with EEG monitoring receiving general anesthesia using the ether anesthetic sevoflurane combined with oxygen and air.
resultsFollowing the transition to nitrous oxide, the alpha (8-12 Hz) oscillations associated with sevoflurane dissipated within 3-12 min (median 6 min) and were replaced by highly coherent large-amplitude slow-delta (0.1-4 Hz) oscillations that persisted for 2-12 min (median 3 min).
conclusionsAdministration of high-dose nitrous oxide is associated with transient, large amplitude slow-delta oscillations. SIGNIFICANCE: We postulate that these slow-delta oscillations may result from nitrous oxide-induced blockade of major excitatory inputs (NMDA glutamate projections) from the brainstem (parabrachial nucleus and medial pontine reticular formation) to the thalamus and cortex. This EEG signature of high-dose nitrous oxide may offer new insights into brain states during general anesthesia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.