Evidence map›Paper›PMID 26117821›Full record

ArticleEuropean journal of medicinal chemistry2015

Metronidazole-triazole conjugates: activity against Clostridium difficile and parasites.

Angie M Jarrad, Tomislav Karoli, Anjan Debnath, Chin Yen Tay, Johnny X Huang, Geraldine Kaeslin, Alysha G Elliott, Yukiko Miyamoto, Soumya Ramu, Angela M Kavanagh and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medicinal chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. A Lactone-Enabled Approach to Metronidazole-Based Scaffolds.The Journal of organic chemistry · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Generation of Markerless Deletions in the Nosocomial PathogenApplied and environmental microbiology · 2019
    Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Angie M JarradDivision of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Tomislav KaroliDivision of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Anjan DebnathSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, 92093, USA.
Chin Yen TayMarshall Centre for Infectious Diseases Research and Training, University of Western Australia, Perth, Western Australia, 6099, Australia.
Johnny X HuangDivision of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Geraldine KaeslinDivision of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Alysha G ElliottDivision of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Yukiko MiyamotoDepartment of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA.
Soumya RamuDivision of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Angela M KavanaghDivision of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Johannes ZueggDivision of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Lars EckmannDepartment of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA.
Mark A T BlaskovichDivision of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Matthew A CooperDivision of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia. Electronic address: m.cooper@uq.edu.au.

Funding

Next-generation 5-nitro heterocyclic antimicrobials against mucosal protistsR01AI114671 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ECKMANN, LARS · 2015 to 2019
$3.1M
The UCSD Digestive Diseases Research Development CenterR24DK080506 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ECKMANN, LARS · 2008 to 2012
$2.7M
Click chemistry for novel antimicrobials against periodontal pathogensRC1DE020607 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ECKMANN, LARS, FOKIN, VALERY V · 2009 to 2010
$962k
NIAID NIH HHS AI114671NIAID NIH HHS HHSN272200700055CNIAID NIH HHS R01 AI114671NIDCR NIH HHS DE020607NIDCR NIH HHS RC1 DE020607NIDDK NIH HHS DK080506NIDDK NIH HHS R24 DK080506Wellcome TrustWellcome Trust 094977/Z/10/Z
6 · The paper itself

Abstract

Metronidazole has been used clinically for over 50 years as an antiparasitic and broad-spectrum antibacterial agent effective against anaerobic bacteria. However resistance to metronidazole in parasites and bacteria has been reported, and improved second-generation metronidazole analogues are needed. The copper catalysed Huigsen azide-alkyne 1,3-dipolar cycloaddition offers a way to efficiently assemble new libraries of metronidazole analogues. Several new metronidazole-triazole conjugates (Mtz-triazoles) have been identified with excellent broad spectrum antimicrobial and antiparasitic activity targeting Clostridium difficile, Entamoeba histolytica and Giardia lamblia. Cross resistance to metronidazole was observed against stable metronidazole resistant C. difficile and G. lamblia strains. However for the most potent Mtz-triazoles, the activity remained in a therapeutically relevant window.

Indexed as

AnimalsAnti-Bacterial AgentsAntiparasitic AgentsCell SurvivalClostridioides difficileDose-Response Relationship, DrugEntamoeba histolyticaGiardia lambliaHEK293 CellsHep G2 CellsHumansMetronidazoleMicrobial Sensitivity TestsMolecular StructureParasitesParasitic Sensitivity TestsAnti-Bacterial AgentsAntiparasitic AgentsMetronidazoleTriazolesAnaerobeAntibioticClick chemistryNitroimidazole

Identifiers

PMID26117821
PMCPMC4550478

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.