Evidence map›Paper›PMID 26117404›Full record

ArticleAtherosclerosis2015

Relationship of pericardial fat with lipoprotein distribution: The Multi-Ethnic study of atherosclerosis.

Kwok-Leung Ong, Jingzhong Ding, Robyn L McClelland, Bernard M Y Cheung, Michael H Criqui, Philip J Barter, Kerry-Anne Rye, Matthew A Allison

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Obesity and its management in primary care setting.Journal of diabetes and its complications · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Association of Pericardial Fat with Cardiac Structure, Function, and Mechanics: The Multi-Ethnic Study of Atherosclerosis.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2022
    Article
  6. Article
  7. Review
  8. Review
  9. Smoking and the Pathophysiology of Peripheral Artery Disease.Frontiers in cardiovascular medicine · 2021
    Review
  10. A Novel Subset of CD95Frontiers in immunology · 2020
    Article
  11. Article
  12. Diet and adipose tissue distributions: The Multi-Ethnic Study of Atherosclerosis.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Kwok-Leung OngCentre for Vascular Research, University of New South Wales, Sydney, NSW 2025, Australia. Electronic address: oklws@yahoo.com.hk.
Jingzhong DingSticht Center on Aging, Wake Forest University School of Medicine, Winston-Salem, NC, United States.
Robyn L McClellandDepartment of Biostatistics, University of Washington, Seattle, WA, United States.
Bernard M Y CheungDepartment of Medicine, University of Hong Kong, Hong Kong, China.
Michael H CriquiDepartment of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, United States.
Philip J BarterCentre for Vascular Research, University of New South Wales, Sydney, NSW 2025, Australia; Faculty of Medicine, University of Sydney, Sydney, NSW, Australia.
Kerry-Anne RyeCentre for Vascular Research, University of New South Wales, Sydney, NSW 2025, Australia; Faculty of Medicine, University of Sydney, Sydney, NSW, Australia.
Matthew A AllisonDepartment of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, United States.
The University of Sydney · AUUniversity of California San Diego · USUniversity of Hong Kong · HKUniversity of Washington · USUNSW Sydney · AUWake Forest University · US

Funding

Abdominal Body Composition, Inflammation and Cardiovascular DiseaaseR01HL088451 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALLISON, MATTHEW A · 2007 to 2011
$2.5M
Pericardial fat and subclinical and clinical measures of coronary heart diseaseR01HL085323 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DING, JINGZHONG · 2006 to 2009
$1.6M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1999 to 2001
$758k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095162 · HC · JOHNS HOPKINS UNIVERSITY · PI SZKLO, MOYSES A · 1999 to 2000
$694k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095161 · HC · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHEA, STEVEN · 1999 to 2001
$642k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095165 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1999 to 2001
$616k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095160 · HC · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAAD, MOHAMMED F · 1999 to 2001
$592k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095164 · HC · NORTHWESTERN UNIVERSITY · PI LIU, KIANG JOHN · 1999 to 2001
$511k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095163 · HC · UNIVERSITY OF MINNESOTA TWIN CITIES · PI FOLSOM, AARON R · 1999 to 2001
$443k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095168 · HC · JOHNS HOPKINS UNIVERSITY · PI BLUEMKE, DAVID A. · 1999 to 2000
$375k
SUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTER-N01HC95159-268095159N01HC095159 · HC · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 1999 to 2006
$304k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READINGN01HC095169 · HC · LA BIOMED RES INST/ HARBOR UCLA MED CTR · PI DETRANO, ROBERT · 1999 to 2001
$124k
NHLBI NIH HHS 5R01-HL-088451NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL085323NHLBI NIH HHS R01-HL-085323NHLBI NIH HHS R01 HL088451
6 · The paper itself

Abstract

objectivePericardial fat and lipoprotein abnormalities contribute to increased risk of cardiovascular disease (CVD). We investigated the relationship between pericardial fat volume and lipoprotein distribution, and whether the association of pericardial fat volume with subclinical atherosclerosis and incident CVD events differs according to lipoprotein distribution.

methodsWe analyzed data from 5407 participants from the Multi-Ethnic Study of Atherosclerosis who had measurements of pericardial fat volume, lipoprotein distribution, carotid intima-media thickness (IMT), and coronary artery calcium (CAC). All participants were free of clinically apparent CVD at baseline. Incident CVD was defined as any adjudicated CVD event.

resultsAfter adjusting for demographic factors, traditional risk factors, and biomarkers of inflammation and hemostasis, a larger pericardial fat volume was associated with higher large VLDL particle (VLDL-P) concentration and small HDL particle (HDL-P) concentration, and smaller HDL-P size (regression coefficients = 0.585 nmol/L, 0.366 μmol/L, and -0.025 nm per SD increase in pericardial fat volume respectively, all P < 0.05). The association of pericardial fat volume with large VLDL-P concentration and HDL-P size, but not small HDL-P concentration, remained significant after further adjusting for each other as well as LDL cholesterol, HDL cholesterol, and triglycerides. The relationship of pericardial fat volume with incident CVD events, carotid IMT, and prevalence and severity of CAC did not differ by quartiles of large VLDL-P concentration, small HDL-P concentration, or HDL-P size (P for interaction>0.05).

conclusionPericardial fat is associated with atherogenic lipoprotein abnormalities. However, its relationship with subclinical atherosclerosis and incident CVD events does not differ according to lipoprotein distribution.

Indexed as

Adipose TissueAgedAged, 80 and overAtherosclerosisCardiovascular DiseasesCarotid Intima-Media ThicknessCholesterol, HDLCholesterol, LDLFemaleHemostasisHumansLipidsLipoproteins, HDLLipoproteins, VLDLLongitudinal StudiesMaleCholesterol, HDLCholesterol, LDLLipidsLipoproteins, HDLLipoproteins, VLDLTriglyceridesCardiovascular diseaseLipidsLipoproteinsPericardial fatSubclinical atherosclerosis

Identifiers

PMID26117404
PMCPMC4510019
OpenAlexW2109288780

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.