Trial reportBiological psychiatry2016
A Prospective 5-Year Re-examination of Alcohol Response in Heavy Drinkers Progressing in Alcohol Use Disorder.
Trial report in Biological psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 4 syntheses or guidelines pooled it, 132 citations in OpenAlex.
- Are medication effects on subjective response to alcohol and cue-induced craving associated? A meta regression study.Psychopharmacology · 2023Pooled it
- The Etiologic, Theory-Based, Ontogenetic Hierarchical Framework of Alcohol Use Disorder: A Translational Systematic Review of Reviews.Psychological bulletin · 2021Pooled it
- A meta-regression of methodological features that predict the effects of medications on the subjective response to alcohol.Alcoholism, clinical and experimental research · 2021Pooled it
- Naltrexone effects on subjective responses to alcohol in the human laboratory: A systematic review and meta-analysis.Addiction biology · 2019Pooled it
- Aversion-resistant alcohol seeking in the human laboratory.Alcohol, clinical & experimental research · 2025Trial
- Acute alcohol rewarding effects as a risk factor for hangover frequency.Addictive behaviors · 2022Trial
- The prospective interactive effects of alcohol expectancies and subjective response on future drinking behavior.Experimental and clinical psychopharmacology · 2022Trial
- Neural correlates of inhibitory control are associated with stimulant-like effects of alcohol.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
- Alcohol subjective responses in heavy drinkers: Measuring acute effects in the natural environment versus the controlled laboratory setting.Alcoholism, clinical and experimental research · 2021Trial
- Poor inhibitory control is associated with greater stimulation and less sedation following alcohol.Psychopharmacology · 2020Trial
- Relationships between generalized impulsivity and subjective stimulant and sedative responses following alcohol administration.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2019Trial
- The Interplay Between Subjective Response to Alcohol, Craving, and Alcohol Self-Administration in the Human Laboratory.Alcoholism, clinical and experimental research · 2019Trial
- Comparison of Subjective Responses to Oral and Intravenous Alcohol Administration Under Similar Systemic Exposures.Alcoholism, clinical and experimental research · 2019Trial
- Effects of oxytocin on stress reactivity and craving in veterans with co-occurring PTSD and alcohol use disorder.Experimental and clinical psychopharmacology · 2019Trial
- Association of Anticipated and Laboratory-Derived Alcohol Stimulation, Sedation, and Reward.Alcoholism, clinical and experimental research · 2017Trial
- Alcohol-induced performance impairment: a 5-year re-examination study in heavy and light drinkers.Psychopharmacology · 2017Trial
- Effect of Alcohol on Encoding and Consolidation of Memory for Alcohol-Related Images.Alcoholism, clinical and experimental research · 2016Trial
- Integrating alcohol response feedback in a brief intervention for young adult heavy drinkers who smoke: A pilot study.Drug and alcohol dependence · 2015Trial
- Testing neurobiological models of reward/incentive sensitization in the continuation of alcohol use disorder (AUD) symptoms in young adults with AUD: A four-year longitudinal study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Expectations versus reality: Associations among anticipated, natural environment, and laboratory-derived alcohol stimulation, sedation, and reward.Experimental and clinical psychopharmacology · 2026Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe main neurobiological theories of the development of addiction, including tolerance, sensitization, incentive-sensitization, and allostasis, have not been tested in longitudinal human alcohol response research. To address this issue, we conducted the first controlled prospective investigation of subjective and neuroendocrine responses to alcohol measured over a 5-year interval in at-risk young adult heavy drinkers (HD) and light drinker control subjects.
methodsParticipants were 156 individuals, 86 heavy drinkers and 70 light drinkers, undergoing an initial oral alcohol challenge testing (.8 g/kg alcohol vs. placebo) and an identical re-examination testing 5 to 6 years later. Alcohol use disorder (AUD) symptoms and drinking behaviors were assessed in the interim follow-up period.
resultsAt re-examination, HD continued to exhibit higher sensitivity on alcohol's stimulating and rewarding effects with lower sensitivity to sedative effects and cortisol reactivity, relative to light drinkers. In HD with high AUD symptom trajectories over follow-up, heightened alcohol stimulation and reward persisted at re-examination. HD with low AUD symptoms showed reduced alcohol stimulation over time and lower reward throughout compared with the HD with high and intermediate AUD symptoms.
conclusionsResults support the early stage phase of the allostasis model, with persistently heightened reward sensitivity and stimulation in heavy drinkers exhibiting AUD progression in early mid-adulthood. While there are multiple pathways to development of a disorder as complex as AUD, maintenance of alcohol stimulatory and rewarding effects may play an important role in the continuation and progression of alcohol addiction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.